Evidence map›Paper›PMID 41887700›Full record

ArticleNan fang yi ke da xue xue bao = Journal of Southern Medical University2026

[Formononetin downregulates P53/SAT1/ACSL4 pathway-mediated ferroptosis to improve hypoxic-ischemic brain injury in neonatal mice].

Tao Guo, Bolin Chen, Xiao Yang, Yanli Zhao, Xiaomin Li, Jiahao He, Jinsha Shi, Hanjun Zuo, Juanjuan Li

Abstract readEnglish Abstract
PubMed Full text at PMC Publisher
In one paragraph

Article in Nan fang yi ke da xue xue bao = Journal of Southern Medical University, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Tao GuoDepartment of Human Anatomy & Histology and Embryology, School of Basic Medical Sciences, Kunming Medical University, Kunming 650500, China.
Bolin ChenDepartment of Human Anatomy & Histology and Embryology, School of Basic Medical Sciences, Kunming Medical University, Kunming 650500, China.
Xiao YangDepartment of Anatomy, School of Basic Medical Sciences, Kunming University of Science and Technology, Kunming 650500, China.
Yanli ZhaoDepartment of Human Anatomy & Histology and Embryology, School of Basic Medical Sciences, Kunming Medical University, Kunming 650500, China.
Xiaomin LiDepartment of Human Anatomy & Histology and Embryology, School of Basic Medical Sciences, Kunming Medical University, Kunming 650500, China.
Jiahao HeDepartment of Anatomy, School of Basic Medical Sciences, Kunming University of Science and Technology, Kunming 650500, China.
Jinsha ShiDepartment of Human Anatomy & Histology and Embryology, School of Basic Medical Sciences, Kunming Medical University, Kunming 650500, China.
Hanjun ZuoDepartment of Human Anatomy & Histology and Embryology, School of Basic Medical Sciences, Kunming Medical University, Kunming 650500, China.
Juanjuan LiDepartment of Human Anatomy & Histology and Embryology, School of Basic Medical Sciences, Kunming Medical University, Kunming 650500, China.

Funding

National Natural Science Foundation of China 32460218 and 31960194
6 · The paper itself

Abstract

objectivesTo investigate the neuroprotective effects of formononetin (FMN) against hypoxic-ischemic brain damage (HIBD) in neonatal mice and the underlying mechanism.

methodsTwenty-four neonatal C57BL/6J mice were randomly divided (

resultsIn the neonatal mouse models of HIBD, FMN treatment significantly suppressed the protein expression of P53, SAT1, and ACSL4, reduced Fe²⁺, ROS, and MDA levels and increased GSH content in the cortical ischemic penumbra. In HT22 neurons with OGD, FMN obviously alleviated OGD-induced ferroptosis as shown by lowered expressions of the key ferroptosis proteins, reduced Fe²⁺ accumulation and lipid peroxidation, and significant increases of GSH levels, mitochondrial membrane potential, and cell viability. Mechanistic experiments showed that activation of P53 signaling by Nutlin-3 markedly reversed the protective effects of FMN.

conclusionsFMN produces neuro-protective effects against HIBD in neonatal mice by mitigating neuronal ferroptosis, primarily through downregulation of the P53/SAT1/ACSL4 signaling pathway.

Indexed as

FerroptosisHypoxia-Ischemia, BrainIsoflavonesTumor Suppressor Protein p53AnimalsAnimals, NewbornCoenzyme A LigasesDown-RegulationMiceMice, Inbred C57BLNeuronsNeuroprotective AgentsSignal TransductionAcsl4 protein, mouseCoenzyme A LigasesformononetinIsoflavonesNeuroprotective AgentsTrp53 protein, mouseTumor Suppressor Protein p53ACSL4ferroptosisformononetinhypoxic-ischemic brain damageP53SAT1

Identifiers

PMID41887700
PMCPMC13021341

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