ArticleNan fang yi ke da xue xue bao = Journal of Southern Medical University2026
[
Article in Nan fang yi ke da xue xue bao = Journal of Southern Medical University, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
Abstract
objectivesTo explore the effect of
methodsCultured A549 cells were treated with osimertinib alone or in combination with SMS-medicated rat serum, and the changes in cell viability and glucose and lactate levels were determined. The effect of SMS combined with osimertinib for improving osimertinib resistance of A549 cells was assessed in a mouse model bearing subcutaneous A549 cell xenograft. Western blotting, RT-qPCR, and immunofluorescence staining were used to analyze the effects of SMS and lactate on the Wnt/β‑catenin/LDHA signaling pathway.
resultsSMS significantly increased osimertinib sensitivity of A549 cells in a concentration-dependent manner. Compared with osimertinib alone, the combined treatment with SMS and osimertinib significantly inhibited cell viability, colony formation ability, and tumor growth in nude mice. SMS concentration-dependently decreased glucose and lactate levels in A549 cells. The results of Western blotting showed that SM inhibited the protein expression of LDHA, total β‑catenin, and cytoplasmic and nuclear β‑catenin, while lactate obviously activated the expressions of total β‑catenin protein, nuclear β‑catenin, and LDHA in A549 cells. Immunofluorescence concentration-dependent staining showed that lactic acid activated nuclear accumulation of β‑catenin protein, while SMS significantly inhibited the expression of nuclear β‑catenin protein; RT-qPCR demonstrated that lactate significantly increased mRNA expressions of the Wnt/β‑catenin downstream target genes (c-myc, CD44, Axin2, Oct3/4, survivin, and CCND1), while SMS inhibited their expressions.
conclusionsSMS improves osimertinib resistance in non-small cell lung cancer cells by inhibiting lactate/Wnt/β-catenin/LDHA pathway-mediated glycolysis.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.