Evidence map›Paper›PMID 41887640›Full record

ArticleBMJ open2026

Prospective randomised trial comparing thermal ablation With laparoscopic Adrenalectomy as an alternatiVE treatment for unilateral asymmetric primary aldosteronism: a protocol for the WAVE trial.

Kate Laycock, Jessica Kearney, Yun-Ni Lee, James Macfarlane, Emily Goodchild, Elisabeth Ng, Antonine Pineau Mitchell, Xilin Wu, Zin Htut, George Goodchild and 21 more

Registry-linked trialAbstract readClinical Trial Protocol
PubMed Full text at PMC Publisher
In one paragraph

Article in BMJ open, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05405101 (A Prospective Randomised Trial Comparing Thermal Ablation With Laparoscopic Adrenalectomy as an alternatiVE Treatment for Unilateral Asymmetric Primary Aldosteronism), which is not on this map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05405101 naactive not recruitingnot on this map

A Prospective Randomised Trial Comparing Thermal Ablation With Laparoscopic Adrenalectomy as an alternatiVE Treatment for Unilateral Asymmetric Primary Aldosteronism

TypeinterventionalSponsorQueen Mary University of LondonRan2022 to 2026Enrolled112ConditionsPrimary AldosteronismArmsThermal ablation of aldosterone producing adenoma., Unilateral adrenalectomy
3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

31 authors.

Kate LaycockQueen Mary University of London, London, UK kate.laycock@nhs.net.ORCID http://orcid.org/0009-0009-0555-7071
Jessica KearneyQueen Mary University of London, London, UK.
Yun-Ni LeeQueen Mary University of London, London, UK.
James MacfarlaneCambridge University Hospitals NHS Foundation Trust, Cambridge, England, UK.
Emily GoodchildQueen Mary University of London, London, UK.
Elisabeth NgSt Bartholomew's Hospital, London, England, UK.
Antonine Pineau MitchellQueen Mary University of London, London, UK.
Xilin WuQueen Mary University of London, London, UK.
Zin HtutImperial College London, London, England, UK.
George GoodchildGastroenterology, St Bartholomew's Hospital, London, England, UK.
Deborah LoweThe Royal London Hospital, London, England, UK.
Nicholas HilliardCambridge University Hospitals NHS Foundation Trust, Cambridge, England, UK.
Edmund GodfreyCambridge University Hospitals NHS Foundation Trust, Cambridge, England, UK.
Nad QaziImperial College London, London, England, UK.
Jose BastosThe Royal London Hospital, London, England, UK.
Aldons ChuaSt Bartholomew's Hospital, London, England, UK.
Razeen MahroofCambridge University Hospitals NHS Foundation Trust, Cambridge, England, UK.
August PalmaCambridge University Hospitals NHS Foundation Trust, Cambridge, England, UK.
Aklima KhatunQueen Mary University of London, London, UK.
Chetna VarsaniSt Bartholomew's Hospital, London, England, UK.
Daniela BenuQueen Mary University of London, London, UK.
Stephen P PereiraInstitute for Liver and Digestive Health, University College London, London, UK.
Mohan KrishnamurthyNuclear Medicine, St Bartholomew's Hospital, London, England, UK.
Heok CheowNuclear Medicine, Cambridge University Hospitals NHS Foundation Trust, Cambridge, England, UK.
Teng-Teng ChungEndocrine, University College London, London, England, UK.
Paul CarrollEndocrine, Guy's and St Thomas' Hospitals NHS Trust, London, England, UK.
Samuel O'TooleSheffield Teaching Hospitals NHS Foundation Trust, Sheffield, England, UK.
Florian WernigImperial College London, London, England, UK.
Mark GurnellCambridge University Hospitals NHS Foundation Trust, Cambridge, England, UK.
M BrownQueen Mary University of London, London, UK.
William M DrakeQueen Mary University of London, London, UK.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionUnilateral aldosterone-producing adenomas (>1 cm) and aldosterone-producing nodules (<1 cm) are a common cause of primary aldosteronism (PA) and hypertension. Adrenal surgery can potentially cure or significantly improve the condition. However, fewer than 1% of patients with PA undergo adrenalectomy. For some, this is due to surgical risks, service capacity or patient preference against surgery. In these individuals, thermal ablation may provide an alternative. This paper describes the protocol for the WAVE trial, designed to compare thermal ablation with the current standard, laparoscopic adrenalectomy, in the treatment of unilateral PA. METHODS AND ANALYSIS: WAVE is a prospective, multicentre, randomised controlled non-inferiority trial comparing thermal ablation (experimental arm) with laparoscopic adrenalectomy (control arm) in the treatment of unilateral PA. 122 participants will be recruited and randomised to thermal ablation or laparoscopic adrenalectomy in a 1.5:1 ratio. Hierarchical co-primary endpoint data considering both biochemical and clinical outcomes will be judged at 6 months. Secondary endpoint data will consider adverse events, length of inpatient stay, patient satisfaction and time to return to activities of daily living. The full protocol is available at ClinicalTrials.gov. ETHICS AND DISSEMINATION: The protocol was approved by the Bloomsbury Research Ethics Committee (21/LO/0243). The results of the study will be shared with study participants, published in peer-reviewed journals and presented at national/international conferences. TRIAL REGISTRATION NUMBER: NCT05405101.

Indexed as

Ablation TechniquesAdrenalectomyHyperaldosteronismLaparoscopyEquivalence Trials as TopicFemaleHumansMulticenter Studies as TopicPatient SatisfactionProspective StudiesRandomized Controlled Trials as TopicTreatment OutcomeAdrenal disordersEndocrine tumoursHypertension

Identifiers

PMID41887640
PMCPMC13034237

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.