Evidence map›Paper›PMID 41887573›Full record

ReviewClinical medicine (London, England)2026

The dilemma of thromboprophylaxis in stroke patients.

Shiksha Guru, Adrian Parry-Jones, Jecko Thachil, Dawn Swan

Abstract readReview
In one paragraph

Review in Clinical medicine (London, England), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Shiksha GuruUniversity of Manchester, Manchester, UK. Electronic address: shiksha.guru@gmail.com.
Adrian Parry-JonesGeoffrey Jefferson Brain Research Centre, Manchester Academic Health Science Centre, Northern Care Alliance NHS Foundation Trust & University of Manchester, Manchester, UK; Division of Cardiovascular Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester, UK.
Jecko ThachilMAHSC Professor, University of Manchester, Manchester, UK.
Dawn SwanDepartment of Haematology, Austin Health, Melbourne, Victoria, Australia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Acute stroke is one of the leading causes of mortality worldwide, with venous thromboembolism (VTE) representing a significant yet under-recognised complication. The risk of VTE is highest in the early post-stroke period, driven by factors encapsulated by Virchow's triad. However, the risk of haemorrhagic transformation following ischaemic stroke, and haematoma development and expansion after haemorrhagic stroke complicate the routine use of pharmacological VTE prophylaxis. In this review, we discuss the epidemiology and aetiology of VTE post-stroke, haemorrhagic transformation after acute ischaemic events, and the available evidence supporting mechanical and pharmacological approaches to VTE prophylaxis in these patients. Finally, we discuss the recommendations provided by the current international consensus guidelines and reasons underpinning the heterogeneous management of patients in routine clinical practice, including the need for well-designed, large-scale clinical trials to better define thromboprophylaxis strategies for patients following acute stroke.

Indexed as

AnticoagulantsStrokeVenous ThromboembolismHumansRisk FactorsAnticoagulantsAnticoagulationHaemorrhageStrokeThrombosis

Identifiers

PMID41887573
PMCPMC13127331

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.