Evidence map›Paper›PMID 41887221›Full record

ArticleCell reports. Medicine2026

CAR-M2 immunotherapy resolves renal fibrosis via revascularization and apoptosis of profibrotic Cxcr2

Wenyan Zhao, Xin Zhou, Xingli Zhao, Hao Tian, Yang Su, Shanlan Zhao, Min Liu, Qiao Zhang, Lin Chen, Xiaochen Li and 10 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell reports. Medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. T-Cell Remodeling in Renal Fibrosis: From Acute Injury to Chronic Kidney Disease.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
    Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors.

Wenyan ZhaoDepartment of Cell Biology, Army Medical University, Chongqing 400038, China; Department of Pain and Rehabilitation, Xinqiao Hospital, Third Military Medical University, Chongqing 400038, China.
Xin ZhouDepartment of Cell Biology, Army Medical University, Chongqing 400038, China.
Xingli ZhaoDepartment of Cell Biology, Army Medical University, Chongqing 400038, China.
Hao TianDepartment of Cell Biology, Army Medical University, Chongqing 400038, China.
Yang SuDepartment of Cell Biology, Army Medical University, Chongqing 400038, China.
Shanlan ZhaoDepartment of Cell Biology, Army Medical University, Chongqing 400038, China.
Min LiuDepartment of Cell Biology, Army Medical University, Chongqing 400038, China.
Qiao ZhangDepartment of Cell Biology, Army Medical University, Chongqing 400038, China.
Lin ChenDepartment of Cell Biology, Army Medical University, Chongqing 400038, China.
Xiaochen LiDepartment of Cell Biology, Army Medical University, Chongqing 400038, China.
Di LiuDepartment of Cell Biology, Army Medical University, Chongqing 400038, China.
Junxuan LiDepartment of Cell Biology, Army Medical University, Chongqing 400038, China.
Lang LiDepartment of Cell Biology, Army Medical University, Chongqing 400038, China.
Yanhong WangDepartment of Cell Biology, Army Medical University, Chongqing 400038, China.
Xingtong LiDepartment of Cell Biology, Army Medical University, Chongqing 400038, China.
Jin YanJinfeng Laboratory, Chongqing 401329, China.
Wen ChenDepartment of Pathology, The 8th Medical Center, Chinese PLA General Hospital, Beijing 100091, China. Electronic address: dr.chen20160224@foxmail.com.
Bing LiuState Key Laboratory of Experimental Hematology, Fifth Medical Center of Chinese PLA General Hospital, Beijing, China. Electronic address: bingliu17@yahoo.com.
Chuhong ZhuDepartment of Anatomy, Engineering Research Center for Organ Intelligent Biological Manufacturing of Chongqing, Key Lab for Biomechanics and Tissue Engineering of Chongqing, Third Military Medical University, Chongqing 400038, China; Engineering Research Center of Tissue and Organ Regeneration and Manufacturing, Ministry of Education, Chongqing 400038, China; State Key Laboratory of Trauma and Chemical Poisoning, Chongqing, China. Electronic address: zhuch99@tmmu.edu.cn.
Wen ZengDepartment of Cell Biology, Army Medical University, Chongqing 400038, China; Jinfeng Laboratory, Chongqing 401329, China; State Key Laboratory of Trauma and Chemical Poisoning, Chongqing, China. Electronic address: zengw0105@tmmu.edu.cn.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Renal fibrosis is a common outcome of chronic kidney disease (CKD), forming a fibrotic niche characterized by fibroblast activation and vascular rarefaction. Currently, there are no effective treatment strategies targeting fibrotic niche. Here, we show that chimeric antigen receptor-modified M2 macrophages (CAR-M2) targeting FAP and secreting interleukin (IL)-4 are delivered via an injectable HAMA-CS hydrogel beneath the renal subcapsule and attenuate renal fibrosis while promoting renal revascularization. The single-cell RNA sequencing reveals the heterogeneity and interaction of stroma and endothelial cells (ECs). A fibrosis-related Cxcr2

Indexed as

ApoptosisEndothelial CellsImmunotherapyKidneyMacrophagesReceptors, Interleukin-8BAnimalsFibroblastsFibrosisHumansMiceMice, Inbred C57BLReceptors, Interleukin-8BCAR-M2Cxcr2(+) ECsFAP(+) fibroblastsHAMA-CS hydrogelrenal fibrosisrevascularization

Identifiers

PMID41887221
PMCPMC13130657

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.