Evidence map›Paper›PMID 41887121›Full record

ArticleSleep medicine2026

Biphasic sleep is a feature of sleep disturbance in SYNGAP1-RD.

Aida Doucoure, Het Patel, Mark A Abboud, Alice Sperry, Sarah K Wanigatunga, Deana Crocetti, Heather Volk, Adam P Spira, Stewart H Mostofsky, Vaishnav Krishnan and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Sleep medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Aida DoucoureNeurology and Developmental Medicine, Kennedy Krieger Institute, 707 N Broadway, 21205, Baltimore, MD, USA.
Het PatelNeurology and Developmental Medicine, Kennedy Krieger Institute, 707 N Broadway, 21205, Baltimore, MD, USA.
Mark A AbboudDepartments of Neurology, Neuroscience and Psychiatry & Behavioral Sciences, Baylor College of Medicine, Houston, TX, USA.
Alice SperryCenter for Neurodevelopmental and Imaging Research (CNIR), Kennedy Krieger Institute Baltimore Maryland, USA.
Sarah K WanigatungaDepartment of Mental Health, Johns Hopkins Bloomberg School of Public Health, 2024 E. Monument St., Rm B309, Baltimore, MD, 21205, USA.
Deana CrocettiCenter for Neurodevelopmental and Imaging Research (CNIR), Kennedy Krieger Institute Baltimore Maryland, USA.
Heather VolkDepartment of Mental Health, Johns Hopkins Bloomberg School of Public Health, 2024 E. Monument St., Rm B309, Baltimore, MD, 21205, USA.
Adam P SpiraDepartment of Mental Health, Johns Hopkins Bloomberg School of Public Health, 2024 E. Monument St., Rm B309, Baltimore, MD, 21205, USA; Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, 707 N Broadway, 21205, Baltimore, MD, USA; Johns Hopkins Center on Aging and Health, 2024 E. Monument Street, 21205, Baltimore, MD, USA.
Stewart H MostofskyDepartment of Neurology Johns Hopkins University School of Medicine, USA; Center for Neurodevelopmental and Imaging Research (CNIR), Kennedy Krieger Institute Baltimore Maryland, USA; Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, 707 N Broadway, 21205, Baltimore, MD, USA.
Vaishnav KrishnanDepartments of Neurology, Neuroscience and Psychiatry & Behavioral Sciences, Baylor College of Medicine, Houston, TX, USA.
Constance Smith-HicksNeurology and Developmental Medicine, Kennedy Krieger Institute, 707 N Broadway, 21205, Baltimore, MD, USA; Department of Neurology Johns Hopkins University School of Medicine, USA. Electronic address: hicksc@kennedykrieger.org.

Funding

Sleep and Circadian Dysfunction, Brain and Neurobehavioral Development in AutismP50HD103538 · NICHD · HUGO W. MOSER RES INST KENNEDY KRIEGER · PI S. Ali Fatemi, Bradley L Schlaggar · 2020 to 2026
$9.9M
Targeted Therapies for Rett SyndromeR01NS113140 · NINDS · JOHNS HOPKINS UNIVERSITY · PI KANNAN, SUJATHA · 2019 to 2023
$2.0M
Dissecting the Developmental and Epileptic Components of Encephalopathy in DEER01NS131399 · NINDS · BAYLOR COLLEGE OF MEDICINE · PI Vaishnav Krishnan · 2023 to 2026
$1.7M
UNRAVELLING THE MECHANISMS OF EPILEPSY-DEPRESSION COMORBIDITY IN A GENETIC MOUSE MODEL OF TEMPORAL LOBE EPILEPSYK08NS110924 · NINDS · BAYLOR COLLEGE OF MEDICINE · PI KRISHNAN, VAISHNAV · 2019 to 2023
$960k
NICHD NIH HHS P50 HD103538NINDS NIH HHS K08 NS110924NINDS NIH HHS R01 NS113140NINDS NIH HHS R01 NS131399
6 · The paper itself

Abstract

STUDY

objectivesSleep problems are common in children with SYNGAP1-Related Disorder (SYNGAP1-RD). The use of devices that objectively estimate sleep are complicated by co-occurring sensory disorders in this population. We examined the feasibility and validity of wrist actigraphy to examine sleep and rest-activity rhythms (RAR).

methodsData from five children with SYNGAP1-RD and 42 typically developing children were analyzed. All children were asked to wear the Actiwatch-2 for 14 continuous days and caregivers were asked to complete a sleep diary and the Children Sleep Health Questionnaire (CSHQ). Parametric (alpha, beta, acrophase, amplitude, up/down mesor, mesor), nonparametric (intradaily variability, interdaily stability, M10/L5 and relative amplitude), and sleep metrics-total sleep time (TST), wake after sleep onset (WASO), fragmentation index (restlessness throughout the rest period), the time of sleep bout onset, the number, and duration of sleep bouts, and the number and duration of wake bouts-were analyzed.

resultsIn children with SYNGAP1-RD, sleep bouts were distributed across the day and night and were consistent with a higher alpha. Fewer sleep bouts occurred in the early morning aligning with parent report of early morning arousal. Although there was no difference in average TST, children with SYNGAP1-RD, had fewer sleep and wake bouts that were longer in duration. Additionally, they had greater WASO and higher fragmentation index, the latter was a strong predictor of subjects with SYNGAP1-RD.

conclusionActigraphy provides an objective measure of sleep that aligns with RAR, is consistent with parent report, and provides an ethological approach to monitoring sleep in children with SYNGAP1-RD.

Indexed as

ras GTPase-Activating ProteinsSleepSleep Wake DisordersActigraphyChildFemaleHumansMaleSleep DurationSurveys and Questionnairesras GTPase-Activating ProteinsSYNGAP1 protein, humanActigraphyNonparametricParametricRest-activity-rhythmsSleep disturbancesSYNGAP1-RD

Identifiers

PMID41887121
PMCPMC13288264

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.