Evidence map›Paper›PMID 41887022›Full record

ArticleVaccine2026

Immunization strategies to prevent malaria in pregnancy - a multistakeholder workshop.

Flavia D'Alessio, Josiane Honkpehedji, Sodiomon Sirima, Benoit Gamain, Nielsen Morten, Nicaise Ndam, Benjamin Mordmüller, Alassane Dicko, Rhanda Adechina, Ange Dossou and 11 more

Abstract read
In one paragraph

Article in Vaccine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

21 authors.

Flavia D'AlessioEuropean Vaccine Initiative, EVI, Germany. Electronic address: flavia.dalessio@euvaccine.eu.
Josiane HonkpehedjiLa Fondation pour la Recherche Scientifique, FORS, Benin.
Sodiomon SirimaGroupe de Recherche Action en Santé, GRAS, Burkina Faso. Electronic address: s.sirima@gras.bf.
Benoit GamainSorbonne Université, INSERM, CNRS, Centre d'Immunologie et des Maladies Infectieuses, CIMI F-75013 Paris, France. Electronic address: benoit.gamain@inserm.fr.
Nielsen MortenUniversity of Copenhagen, UCPH, Denmark. Electronic address: mortenn@sund.ku.dk.
Nicaise NdamInstitut de Recherche pour le Développement, IRD, France. Electronic address: nicaise.ndam@ird.fr.
Benjamin MordmüllerRadboud University Medical Center, Radboudumc, the Netherlands. Electronic address: benjamin.mordmueller@radboudumc.nl.
Alassane DickoMalaria Research and Training Center, University of Science, Techniques and Technologies of Bamako, Bamako, Mali. Electronic address: adicko@icermali.org.
Rhanda AdechinaAfrican Vaccine Regulatory Forum (AVAREF), Brazzaville, Congo.
Ange DossouMinistry of Health, Benin. Electronic address: addossou@gouv.bj.
Jobiba ChinkhumbaKamuzu University of Health Sciences, KUHeS, Malawi. Electronic address: jchinkhumba@kuhes.ac.mw.
Mandeep KaurEuropean Vaccine Initiative, EVI, Germany. Electronic address: mandeep.kaur@euvaccine.eu.
Roch HoungnihinUniversity d'Abomey, Benin. Electronic address: roch.houngnihin@uac.bj.
D Scott LaMontagneInternatinal Division, JSI Research & Training Institute, Arlington, VA, USA. Electronic address: scott.lamontagne@jsi.org.
Clara MenendezBarcelona Institute for Global Health, ISGlobal, Spain. Electronic address: clara.menendez@isglobal.org.
Adidja AmaniAMVIRA (Accelerated Malaria Vaccine Introduction and Roll-out in Africa), WHO Regional Office for Africa, Brazzaville, Congo. Electronic address: amaniad@who.int.
Tendai MayaniMothers2Mothers, South Africa. Electronic address: Tendai.Mayani@m2m.org.
Mary J HamelIndependent Consultant, Switzerland.
Elvira CarrióP95 Clinical and Epidemiology Services, Leuven, Belgium. Electronic address: Elvira.carrio@p-95.com.
Aicha SayehEuropean Vaccine Initiative, EVI, Germany. Electronic address: aicha.sayeh@euvaccine.eu.
Ayola Akim AdegnikaLa Fondation pour la Recherche Scientifique, FORS, Benin; Centre de Recherces Medicales de Lambarene, CERMEL, Gabon; German Center for Infection Research (DZIF), Partner site Tübingen, Tübingen, Germany; Institut für Tropenmedizin, Universitätsklinikum Tübingen, Germany. Electronic address: ayola-akim.adegnika@uni-tuebingen.de.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

As part of the ADVANCE-VAC4PM project, the European Vaccine Initiative (EVI) and La Fondation pour la Recherche Scientifique (FORS) co-hosted a hybrid workshop titled "Strategies for using malaria vaccines to prevent malaria in pregnancy (MiP)". The event brought together researchers, regulators, civil society, global health experts, and policymakers to discuss the need for MiP vaccines and strategies for their development, evaluation, and implementation. Malaria remains a major global health threat, with sub-Saharan Africa bearing the highest burden. Pregnant women (PW) are highly vulnerable, with an estimated 12.4 million affected in 2023. Beyond maternal health effects, a major cause of the MiP-related disease burden is placental malaria (PM), which can cause significant morbidity in newborns. PM risk is greatest in primigravidae and secundigravidae, as immunity develops over successive pregnancies. As existing malaria control strategies remain insufficient, MiP vaccines have the potential to complement them by eliciting immunity comparable to that seen in multigravidae. To be effective, such a vaccine should provide long-lasting immunity and target adolescent girls and women before their first pregnancy. PM vaccine candidates targeting the VAR2CSA antigen (PRIMVAC and PAMVAC) are in development, and existing malaria vaccines preventing infection are being repurposed to prevent MiP. However, limited awareness of MiP-specific burden, weak pharmacovigilance systems, and vaccine hesitancy may hinder future vaccine implementation. Key recommendations highlighted during the workshop included strengthening communication and community engagement strategies, defining relevant efficacy endpoints for pivotal clinical trials, reinforcing pharmacovigilance systems to support safety and real-world effectiveness studies, and planning for early regulatory alignment. Panel discussions emphasized the importance of stakeholder coordination and reduced-dose schedules to support future MiP vaccine programmatic feasibility. The workshop concluded with a call for sustained collaboration and national investment to ensure that MiP vaccines become a viable and effective component of global malaria prevention efforts.

Indexed as

MalariaMalaria VaccinesPregnancy Complications, ParasiticFemaleHumansPregnancyVaccinationVaccine DevelopmentMalaria VaccinesMalaria in pregnancyPlacental malariaVaccine developmentVaccine implementation

Identifiers

PMID41887022
PMCPMC13147148

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.