Evidence map›Paper›PMID 41887002›Full record

ArticleCancer treatment and research communications2026

The association between parity, age of first full term pregnancy and invasive lobular breast cancer: a case-only analysis.

Karen Van Baelen, Ha Linh Nguyen, François Richard, Maja Vangoitsenhoven, Giuseppe Floris, Hans Wildiers, Ann Smeets, Ines Nevelsteen, Frederic Amant, Christine Desmedt and 1 more

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Article in Cancer treatment and research communications, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

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5 · Who and what money

Authors and funding

11 authors.

Karen Van BaelenLaboratory for Translational Breast Cancer Research, Department of Oncology, KU Leuven, Leuven, Belgium; Department of Gynecological Oncology, UZ Leuven, Leuven, Belgium.
Ha Linh NguyenLaboratory for Translational Breast Cancer Research, Department of Oncology, KU Leuven, Leuven, Belgium.
François RichardLaboratory for Translational Breast Cancer Research, Department of Oncology, KU Leuven, Leuven, Belgium.
Maja VangoitsenhovenDepartment of Gynecological Oncology, UZ Leuven, Leuven, Belgium.
Giuseppe FlorisDepartment of Pathology, UZ Leuven, Leuven, Belgium; Laboratory of Translational Cell & Tissue Research, Department of Imaging and Pathology, KU Leuven, Leuven, Belgium.
Hans WildiersDepartment of General Medical Oncology, UZ Leuven, Leuven, Belgium.
Ann SmeetsDepartment of Surgical Oncology, UZ Leuven, Leuven, Belgium.
Ines NevelsteenDepartment of Surgical Oncology, UZ Leuven, Leuven, Belgium.
Frederic AmantDepartment of Gynecological Oncology, UZ Leuven, Leuven, Belgium; Gynecological Oncology, Department of Oncology, KU Leuven, Leuven, Belgium.
Christine DesmedtLaboratory for Translational Breast Cancer Research, Department of Oncology, KU Leuven, Leuven, Belgium. Electronic address: christine.desmedt@kuleuven.be.
Patrick NevenDepartment of Gynecological Oncology, UZ Leuven, Leuven, Belgium. Electronic address: patrick.neven@uzleuven.be.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeThe risk for estrogen receptor positive/HER2-negative (ER+/HER2-) breast cancer (BC) is transiently augmented in the first years after giving birth especially if the first birth is occurring at a later age. Later in life, high parity and early first full-term pregnancy (1st FTP) appear to be protective for ER+/HER2- BC. The impact of reproductive factors on invasive lobular carcinoma (ILC) is poorly studied. We aimed at retrospectively investigating the association between reproductive factors (parity and age at 1st FTP) and the prevalence and clinicopathological features of ER+/HER2- ILC.

methodsWe considered patients primarily diagnosed with non-metastatic ER+/HER2- BC at University Hospitals Leuven, Belgium, between January 2000 and November 2020. Pure ILC cases were compared in a case-only design to a reference group including all other histological subtypes per parity and age at 1st FTP using linear regression models.

results7360 patients were included, of which 1121 (15.2%) were diagnosed with pure ER+/HER2- ILC. A parity greater than two children was associated with a higher prevalence of pure ILC compared to uniparous patients (OR 1.28, 95%CI 1.06-1.55, p-value 0.011). No significant association was seen for parity equal to two compared to one or for age at 1st FTP <21 vs. 21-25, 26-30 and ≥30. In patients with pure ER+/HER2- ILC, no significant associations were seen between parity and the clinicopathological features.

conclusionsWithin an ER+/HER2- BC cohort, higher parity seems to be associated with a higher prevalence of pure ILC. No association was found between parity and clinicopathological features of ER+/HER2- pure ILC.

Indexed as

Breast NeoplasmsCarcinoma, LobularParityAdultAge FactorsBelgiumErb-b2 Receptor Tyrosine KinasesFemaleHumansMaternal AgeMiddle AgedPregnancyReceptors, EstrogenRetrospective StudiesERBB2 protein, humanErb-b2 Receptor Tyrosine KinasesReceptors, EstrogenAge at first full term pregnancyClinicopathological featuresInvasive lobular carcinomaParity

Identifiers

PMID41887002
PMCPMC13194091

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