ReviewCurrent opinion in genetics & development2026
Convergent re-evolution of CNS structures: focus on the fovea.
Review in Current opinion in genetics & development, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- An NR2F1-dependent retinoic acid network controls retinal specialization in mice and reveals foveal hypoplasia in patients with BBSOAS.bioRxiv : the preprint server for biology · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author.
Funding
Abstract
The fovea is a specialized retinal region that supports high-acuity vision through extreme photoreceptor and ganglion cell densities and near one-to-one circuit connectivity. Although present only in a subset of vertebrates, foveae share core functional principles while differing widely in morphology, cellular composition, number, and retinal location, indicating multiple independent evolutionary origins. Here, I review comparative, developmental, and genomic evidence that the fovea represents a case of convergent re-evolution built on conserved central nervous system patterning mechanisms. I highlight retinoic acid signaling as the earliest known molecular pathway demarcating foveal progenitors across distantly related species and discuss how evolutionary modulation of this positional system may repeatedly generate high-acuity retinal specializations.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.