ArticleObesity facts2026
The Association between the Obesogenic Environment and BMI Independent of Familial Factors: A Cross-Sectional Twin Study.
Article in Obesity facts, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
introductionTo investigate the association between the obesogenic environment and body mass index (BMI), independent of familial factors shared by twins (e.g., genetic and early life environmental factors).
methodsThis cross-sectional twin study included 2,764 adults (77% female, 72% monozygotic [MZ], mean age 40 [SD 14]) from the Dutch Twin Registry. The Obesogenic Built Environment CharacterisTics (OBCT) index was used as neighborhood "obesogenic" exposure, integrating food-environment healthiness, walkability, drivability, and sports facilities within a 1,000 m Euclidean buffer around the residential address. Univariate twin models established the heritability estimates of the OBCT-index and BMI. Full-informed maximum likelihood linear regressions determined individual and pairwise difference (i.e., within-twin-pair differences in outcome and exposure) associations between the OBCT-index and BMI.
resultsThe heritability of the OBCT-index was 9% and common environmental factors explained 27% of its variation, whereas the BMI heritability was 75%. Living in a 10% higher OBCT-index environment was associated with a mean [95% CI] 0.15 [0.07, 0.24] kg/m2 higher BMI in all twin individuals. However, this association was nonsignificant in the MZ and same-sex DZ twin pairwise difference analyses.
conclusionThis study found a small association between a more obesogenic environment and a higher BMI, yet the association was explained by familial confounding. Future research in larger, more environmentally diverse international twin cohorts is needed to elucidate gene-environment interactions.
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