Evidence map›Paper›PMID 41886450›Full record

ArticleCell reports2026

The nBAF complex subunit CREST/SS18L1 regulates hippocampal memory processes via tyrosine 397 and histone acetyltransferase CBP.

Franklin G Garcia, Maria Farias de Albuquerque, Vanessa Johnson, Enikö Kramár, Kousha Changizi, Sherif Abdelkarim, Agatha S Augustynski, Dina P Matheos, Joseph Picone, Tracy L Fetterly and 7 more

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In one paragraph

Article in Cell reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Franklin G GarciaDepartment of Neurobiology and Behavior, Charlie Dunlop School of Biological Sciences, University of California, Irvine, Irvine, CA 92697, USA; Center for the Neurobiology of Learning and Memory, University of California, Irvine, Irvine, CA 92697, USA.
Maria Farias de AlbuquerqueDepartment of Neurobiology and Behavior, Charlie Dunlop School of Biological Sciences, University of California, Irvine, Irvine, CA 92697, USA; Center for the Neurobiology of Learning and Memory, University of California, Irvine, Irvine, CA 92697, USA.
Vanessa JohnsonDepartment of Neurobiology and Behavior, Charlie Dunlop School of Biological Sciences, University of California, Irvine, Irvine, CA 92697, USA; Center for the Neurobiology of Learning and Memory, University of California, Irvine, Irvine, CA 92697, USA.
Enikö KramárDepartment of Neurobiology and Behavior, Charlie Dunlop School of Biological Sciences, University of California, Irvine, Irvine, CA 92697, USA; Center for the Neurobiology of Learning and Memory, University of California, Irvine, Irvine, CA 92697, USA.
Kousha ChangiziDepartment of Computer Science, Institute for Genomics and Bioinformatics, University of California, Irvine, Irvine, CA 92697, USA.
Sherif AbdelkarimDepartment of Computer Science, Institute for Genomics and Bioinformatics, University of California, Irvine, Irvine, CA 92697, USA.
Agatha S AugustynskiDepartment of Neurobiology and Behavior, Charlie Dunlop School of Biological Sciences, University of California, Irvine, Irvine, CA 92697, USA; Center for the Neurobiology of Learning and Memory, University of California, Irvine, Irvine, CA 92697, USA.
Dina P MatheosDepartment of Neurobiology and Behavior, Charlie Dunlop School of Biological Sciences, University of California, Irvine, Irvine, CA 92697, USA; Center for the Neurobiology of Learning and Memory, University of California, Irvine, Irvine, CA 92697, USA.
Joseph PiconeDepartment of Neurobiology and Behavior, Charlie Dunlop School of Biological Sciences, University of California, Irvine, Irvine, CA 92697, USA; Center for the Neurobiology of Learning and Memory, University of California, Irvine, Irvine, CA 92697, USA.
Tracy L FetterlyDepartment of Neurobiology and Behavior, Charlie Dunlop School of Biological Sciences, University of California, Irvine, Irvine, CA 92697, USA; Center for the Neurobiology of Learning and Memory, University of California, Irvine, Irvine, CA 92697, USA.
Alyssa RodriguezDepartment of Neurobiology and Behavior, Charlie Dunlop School of Biological Sciences, University of California, Irvine, Irvine, CA 92697, USA; Center for the Neurobiology of Learning and Memory, University of California, Irvine, Irvine, CA 92697, USA.
Jessica ChildsDepartment of Neurobiology and Behavior, Charlie Dunlop School of Biological Sciences, University of California, Irvine, Irvine, CA 92697, USA; Center for the Neurobiology of Learning and Memory, University of California, Irvine, Irvine, CA 92697, USA.
Angela Gomez-ArboledasInstitute for Memory Impairments and Neurological Disorders, University of California, Irvine, Irvine, CA, USA.
Julia WinterDepartment of Systems Pharmacology & Translational Therapeutics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
Elizabeth HellerDepartment of Systems Pharmacology & Translational Therapeutics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
Pierre BaldiDepartment of Computer Science, Institute for Genomics and Bioinformatics, University of California, Irvine, Irvine, CA 92697, USA.
Marcelo A WoodDepartment of Neurobiology and Behavior, Charlie Dunlop School of Biological Sciences, University of California, Irvine, Irvine, CA 92697, USA; Center for the Neurobiology of Learning and Memory, University of California, Irvine, Irvine, CA 92697, USA. Electronic address: mwood@uci.edu.

Funding

Univ.of Calif., Irvine Cancer Center Support GrantP30CA062203 · NCI · UNIVERSITY OF CALIFORNIA-IRVINE · PI Melanie Funes · 1994 to 2026
$57.9M
Training in the Neurobiology of Aging and Alzheimers DiseaseT32AG000096 · NIA · UNIVERSITY OF CALIFORNIA-IRVINE · PI VIVEK SWARUP, Craig E Stark · 1985 to 2026
$9.6M
Epigenetic mechanisms of sustained transcription across cocaine abstinenceR01DA052465 · NIDA · UNIVERSITY OF PENNSYLVANIA · PI Elizabeth A Heller · 2021 to 2026
$4.0M
Investigating the interface of epigenetics and metabolism underlying memory formation in the adult, aging, and AD brainR01AG076835 · NIA · UNIVERSITY OF CALIFORNIA-IRVINE · PI Marcelo Andres Wood · 2022 to 2026
$3.6M
Bioinformatics Tools for Circadian BiologyR01GM123558 · NIGMS · UNIVERSITY OF CALIFORNIA-IRVINE · PI Pierre Baldi · 2017 to 2026
$2.4M
Role of Neuron-Specific Nucleosome Remodeling in Intellectual DisabilityR01MH101491 · NIMH · UNIVERSITY OF CALIFORNIA-IRVINE · PI LYNCH, GARY S, WOOD, MARCELO ANDRES · 2013 to 2017
$2.3M
Investigating the role of Crest, an epigenetic mechanism coordinator, in the adult and aging/AD brainF32AG077872 · NIA · UNIVERSITY OF CALIFORNIA-IRVINE · PI GARCIA, FRANKLIN · 2022 to 2022
$72k
NCI NIH HHS P30 CA062203NIA NIH HHS F32 AG077872NIA NIH HHS R01 AG076835NIA NIH HHS T32 AG000096NIDA NIH HHS R01 DA052465NIGMS NIH HHS R01 GM123558NIMH NIH HHS R01 MH101491
6 · The paper itself

Abstract

Chromatin-modifying and -remodeling machineries are important for learning-induced transcriptional activity, yet it remains unclear how they coordinate to drive de novo gene expression for memory formation. Here, we examine the transcription factor known as calcium-responsive transactivator (CREST) in memory formation, synaptic plasticity, and learning-induced gene expression. CREST is known to bind major chromatin-modifying and -remodeling machineries via interaction with CREB-binding protein (CBP) and brahma-related gene 1 (BRG1), respectively. In silico modeling of CREST identified tyrosine 397 (Y397) within the CBP-binding domain. Expression of a CREST Y397F point mutant impairs long-term potentiation and memory. Conversely, expression of a CREST Y397D point mutant enhances memory in a CBP-dependent manner. Differential gene expression analysis reveals distinct CREST Y397-regulated signatures during memory consolidation. CBP acts through CREB and post-translation modifications to affect memory, but the findings of this study argue for consideration of the CREST-CBP interaction and Y397 accessibility as factors in memory processes.

Indexed as

CBPCP: genomicsCP: neuroscienceCREB-binding proteinCREST/SS18L1CREST Y397Cyber-TdCA1hippocampal dorsal CA1learning-induced differentially expressed geneslong-term memorylong-term potentiationLTMLTPobject location memoryOLMRNA-seq

Identifiers

PMID41886450
PMCPMC13189212

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.