ArticleAnnals of work exposures and health2026
Enhancing a job exposure matrix with subject-specific information to assess combined exposure to benzene, toluene, and xylene in a case-control study.
Article in Annals of work exposures and health, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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Who cites it
1 citing paper in PubMed.
- Occupational exposure to organic solvents and risk of bladder cancer.Journal of exposure science & environmental epidemiology · 2024Article
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Authors and funding
10 authors.
Funding
Abstract
objectivesWe modified an existing job-exposure matrix (CANJEM) to estimate the combined exposure to benzene, toluene, and xylene, which are highly correlated (hereafter, BTX), and integrated subject-specific occupational information to assess BTX exposure for participants in a bladder cancer case-control study.
methodsWe linked CANJEM to the lifetime occupational histories of subjects in a population-based case-control study of bladder cancer. We derived CANJEM-based estimates of the probability, intensity, and frequency of BTX exposure by assigning the highest rating observed among the benzene, toluene, and xylene CANJEM metrics. We used subject-specific exposure information in the occupational histories and exposure-oriented modules to refine the CANJEM-based BTX metrics when confirmatory exposure information was identified (hereafter, hybrid BTX metrics). We compared agreement between the CANJEM-based and hybrid BTX metrics at the job- and subject-level using kappa for the ordinal probability metrics and Spearman correlation for the continuous intensity and cumulative exposure metrics.
resultsThe hybrid BTX approach increased 7% and decreased 5% of the CANJEM-based BTX probability ratings at the job-level and 16% and 7% at the subject-level, respectively. The CANJEM-based and hybrid BTX metrics identified 3.2% and 6.8% of the job records and 13% and 24% of the subjects as having a high probability of BTX exposure, respectively. The BTX-exposed subjects identified through the hybrid approach generally had lower cumulative exposures than those identified solely using CANJEM. CANJEM-based and hybrid BTX metrics had moderate agreement at the subject-level (probability: kappa = 0.62; cumulative metrics, Spearman correlation = 0.61).
conclusionsSupplementing a JEM with subject-specific exposure information identified within-job exposure heterogeneity that was not captured by using only a JEM.
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