ArticlePloS one2026
Genetic variations associated with immediate hypersensitivity reactions to iodinated contrast media: A whole exome sequencing study.
Article in PloS one, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Article
Corrections and comments
- Erratum issued
Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveThe use of iodinated contrast media (ICM) in computed tomography (CT) has increased significantly; however, hypersensitivity reactions (HSRs) remain a concern. This study aimed to investigate genetic factors associated with ICM-induced immediate HSRs using whole exome sequencing (WES). MATERIALS AND
methodsWe conducted a case-control study including 20 patients with ICM-induced immediate HSRs and 11 controls who had received ICM at least three times without HSRs. WES was performed with DNA extracted from saliva samples. Analyses included single-nucleotide variant (SNV) association testing using the Cochran-Armitage trend test with false discovery rate (FDR) correction, gene-wise variant burden (GVB) analysis, and copy number variation (CNV) detection using complementary algorithms.
resultsA variant in FAST kinase domain 1 (FASTKD1, rs12618227) was significantly more prevalent in the control group compared with the case group (72.7% vs. 5.0%, FDR p < 0.10), suggesting a protective role. GVB analysis revealed lower scores for FASTKD1 and 2-hydroxyacyl-CoA lyase 1 (HACL1) in the control group (nominal p < 0.001). CNV analysis identified a significant Signal Regulatory Protein Beta 1 (SIRPB1) deletion in the case group (5/20, 25.0%). In contrast, CNVs in Mucin 12, cell surface associated (MUC12) were observed in both groups. Immune cell expression data showed high expression of FASTKD1, HACL1, and SIRPB1 in granulocytes, particularly basophils.
conclusionFASTKD1 and HACL1, which are involved in mitochondrial and metabolic regulation, and SIRPB1, which participates in innate immune signaling, were identified as candidate genes potentially associated with ICM-induced immediate HSRs. These suggest a possible contribution of both metabolic and immune regulatory pathways to genetic susceptibility and require validation in larger, independent cohorts before clinical application.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.