ArticleShock (Augusta, Ga.)2026
Diffuse Correlation Spectroscopy for Noninvasive Monitoring of Peripheral Perfusion During Cardiogenic Shock and VA-ECMO Support: An Experimental Study.
Article in Shock (Augusta, Ga.), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
16 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveIn cardiogenic shock (CS), persistent microcirculatory impairment despite improved macrocirculatory parameters is associated with poor outcomes. Therapeutic strategies must therefore address both macro- and microcirculation. Conventional microcirculatory measures have limitations, especially during venoarterial extracorporeal membrane oxygenation support (VA-ECMO). Diffuse correlation spectroscopy (DCS) is a novel optical technique enabling continuous, noninvasive evaluation of microvascular blood flow. This study evaluated DCS for monitoring microcirculation in CS under VA-ECMO.
methodsSeven male beagle dogs (median weight 10.1 kg) underwent CS induction by coronary ligation followed by ventricular fibrillation (VF). VA-ECMO (80-100 mL·kg -1 ·min -1 ) was initiated 5 minutes after VF onset and maintained for 90 minutes under nonpulsatile flow. After stabilization, VA-ECMO flow was reduced from 100 to 30 mL·kg -1 ·min -1 , and mean arterial pressure (MAP) was increased to ≥65 mmHg using vasoconstrictors. Measurements included MAP, cardiac output, and microcirculatory parameters [DCS-derived blood flow index (BFI), perfusion index, skin blood flow, tissue oxygen saturation, mixed venous oxygen saturation, and lactate].
resultsCoronary ligation caused progressive declines in MAP, cardiac output, and microcirculatory indices. MAP [median (interquartile range)] was 109.6 (95.8, 119.7) at baseline and 45.7 (26.3, 51.6) mmHg at CS onset. During VF, perfusion index became unmeasurable while BFI rapidly fell to near zero, detecting peripheral flow loss under nonpulsatile conditions. VA-ECMO initiation restored MAP and mixed venous oxygen saturation, with gradual recovery of BFI and skin blood flow. Reducing VA-ECMO flow lowered MAP [64.7 (62.3, 69.9) to 36.4 (34.4, 44.6) mmHg] and BFI [3.6 (3.4, 5.1) to 1.0 (0.8, 1.2) × 10 -9 ·cm 2 ·s -1 ]. Vasopressors increased MAP [83.1 (79.0, 89.1) mmHg] but failed to improve BFI [1.5 (1.3, 2.1) × 10 -9 ·cm 2 ·s -1 ], indicating persistent microcirculatory impairment.
conclusionsDCS continuously detected microvascular changes during CS and VA-ECMO support regardless of pulsatility. DCS may be useful for early identification of microcirculatory dysfunction and optimization of therapy in CS.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.