Evidence map›Paper›PMID 41886365›Full record

ReviewThe Plant journal : for cell and molecular biology2026

The transformative power of structural predictions with AI in plant science.

Joy Chenqu Lyu, Renier A L Van der Hoorn

Abstract readReview
In one paragraph

Review in The Plant journal : for cell and molecular biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Joy Chenqu LyuThe Plant Chemetics Laboratory, Department of Biology, University of Oxford, Oxford, UK.
Renier A L Van der HoornThe Plant Chemetics Laboratory, Department of Biology, University of Oxford, Oxford, UK.ORCID 0000-0002-3692-7487

Funding

Biotechnology and Biological Sciences Research Council DDT00230European Research Council 101019324
6 · The paper itself

Abstract

Since the introduction of various structural prediction programs, the emerging transformative power of these technologies in plant science is apparent. Not only programs like AlphaFold but also RoseTTAFold, Chai-1 and Boltz suddenly enable plant scientists to predict structures with high confidence. This ability has facilitated the discovery of novel protein functions inspired by structural homology and provided novel insights into how proteins evolved from ancestral folds. Prediction of protein oligomers and their interactions with lipids was crucial for studying immune receptors that assemble into resistosomes, while prediction of peptide-protein interactions has enabled the engineering of broad-range cell surface receptors. In silico screens for novel protein interactions identified novel autophagy receptors and inhibitors of immune hydrolases. More discoveries will soon follow with the development of new tools to predict and analyse structures. These and many other recent discoveries highlight the transformative power of structural predictions with artificial intelligence in plant science.

Indexed as

Artificial IntelligenceBotanyPlant ProteinsPlantsPrediction AlgorithmsProtein ConformationPlant ProteinsAlphaFoldplant scienceprotein complexesprotein structurestructure prediction

Identifiers

PMID41886365
PMCPMC13020896

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.