Evidence map›Paper›PMID 41886268›Full record

ArticleAmerican journal of physiology. Renal physiology2026

Stimulation of basolateral calcium-sensing receptor inhibits Kir4.1/Kir5.1 in the mouse distal convoluted tubule.

Junlin Wang, Jiawen Zhang, Shumin Kong, Ping Ma, Zhen Zhang, Lijun Wang, Wen-Hui Wang, Rui-Min Gu

Abstract read
In one paragraph

Article in American journal of physiology. Renal physiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Junlin WangDepartment of Physiology, Heilongjiang Chinese Medicine University, Harbin, China.ORCID 0000-0003-1463-1690
Jiawen ZhangDepartment of Pathology, Heilongjiang Chinese Medicine University, Harbin, China.ORCID 0000-0003-3707-0590
Shumin KongDepartment of Nephrology, The Second Hospital of Suzhou University, Suzhou, China.
Ping MaDepartment of Physiology, Harbin Medical University, Harbin, China.
Zhen ZhangDepartment of Physiology, Harbin Medical University, Harbin, China.ORCID 0009-0005-4942-5565
Lijun WangDepartment of Physiology, Harbin Medical University, Harbin, China.ORCID 0000-0002-3169-2420
Wen-Hui WangDepartment of Pharmacology, New York Medical College, Valhalla, New York, United States.ORCID 0000-0002-7503-9554
Rui-Min GuDepartment of Physiology, Harbin Medical University, Harbin, China.ORCID 0000-0002-9906-3866

Funding

Role of Kir4.1 in regulating NCC and ROMK in DCTR01DK133220 · NIDDK · NEW YORK MEDICAL COLLEGE · PI ELLISON, DAVID HOADLEY, WANG, WENHUI · 2022 to 2025
$2.6M
HHS | NIH | National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) DK133220NIDDK NIH HHS R01 DK133220
6 · The paper itself

Abstract

The calcium-sensing-receptor (CaSR) is expressed in the basolateral membrane of distal convoluted tubule (DCT) and CaSR expression inhibited Kir4.1 in cells expressing

Indexed as

Kidney Tubules, DistalPotassium Channels, Inwardly RectifyingReceptors, Calcium-SensingAnimalsCalciumKcnj10 ChannelKir5.1 ChannelMaleMembrane PotentialsMiceMice, Inbred C57BLPhenethylaminesPropylaminesProtein Kinase CSignal TransductionType C PhospholipasesCalciumCASR protein, mouseKcnj10 ChannelKir5.1 ChannelN-(2-chlorophenylpropyl)-1-(3-methoxyphenyl)ethylaminePhenethylaminesPotassium Channels, Inwardly RectifyingPropylaminesProtein Kinase CReceptors, Calcium-SensingType C Phospholipasescalcium-sensing receptorDCTKcnj10Kcnj16kidney Ca2+ transport

Identifiers

PMID41886268
PMCPMC13131289

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.