Evidence map›Paper›PMID 41886255›Full record

ArticleTissue engineering and regenerative medicine2026

Poly(2-Methacryloxyethyl Phosphorylcholine-Co-Butyl Methacrylate) Coating Enhances Biomimetic Mineralization of Bioglass and Promotes Cellular Proliferation.

Hye June Byun, Mi Yeon Ha, Gun-Jae Jeong, Dae Hyeok Yang, Jeong Ho Chang, Ju Woong Jang, Yasuhiko Iwasaki, Jae Taek Hong, Heung Jae Chun

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Article in Tissue engineering and regenerative medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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4 · The record

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5 · Who and what money

Authors and funding

9 authors.

Hye June Byun *Department of Medical Sciences, College of Medicine, The Catholic University of Korea, Seoul, 06591, Republic of Korea.
Mi Yeon Ha *Institute of Cell and Tissue Engineering, College of Medicine, The Catholic University of Korea, Seoul, 06591, Republic of Korea.
Gun-Jae JeongInstitute of Cell and Tissue Engineering, College of Medicine, The Catholic University of Korea, Seoul, 06591, Republic of Korea.
Dae Hyeok YangInstitute of Cell and Tissue Engineering, College of Medicine, The Catholic University of Korea, Seoul, 06591, Republic of Korea.
Jeong Ho ChangDivision of Bioconvergence Materials, Korea Institute of Ceramic Engineering and Technology, Chungbuk, 28160, Korea.
Ju Woong JangRenew Medical Co. Ltd. Jeongju-Ro, Bucheon-Si, Gyeonggi-Do, 14532, Republic of Korea.
Yasuhiko IwasakiFaculty of Chemistry, Materials and Bioengineering, Kansai University, Osaka, 564-8680, Japan.
Jae Taek HongDepartment of Neurosurgery, College of Medicine, Eunpyeong St. Mary's Hospital, The Catholic University of Korea, Seoul, 03312, Republic of Korea. jatagi15@catholic.ac.kr.
Heung Jae ChunDepartment of Medical Sciences, College of Medicine, The Catholic University of Korea, Seoul, 06591, Republic of Korea. chunhj@catholic.ac.kr.ORCID http://orcid.org/0000-0002-0446-9901

Funding

Ministry of Trade, Industry and Energy 20018324
6 · The paper itself

Abstract

backgroundBiologically active glasses (BG) are widely studied as potential materials for bone tissue engineering, owing to their capacity to form hydroxyapatite (HA) layers when exposed to body fluids. However, the demerit of BG is the slow deposition rate of calcium ions on the surface, a key factor in increasing the conversion rate to mineralization. The purpose of this study is to introduce phosphoryl group recognized as a trigger for the nucleation processes of apatite formation on the surface of BG.

methodsBG was coated with poly (2-methacryloyloxyethyl phosphorylcholine) (PMB) and characterized via Fourier-transform infrared spectroscopy (FT-IR), scanning electron microscopy (SEM), and X-ray photoelectron spectroscopy (XPS). Biomimetic mineralization was evaluated through simulated body fluid (SBF) immersion, X-ray diffraction (XRD). In vitro MG-63 cell responses were assessed and compared among BG, BG/HA, BG/2%PMB, and BG/2%PMB/HA groups.

resultsResults demonstrated that the PMB coating successfully promoted mineralization by introducing negatively charged phosphate groups that enhanced crystallization. BG/2%PMB/HA significantly upregulated focal adhesion markers in MG-63 cells, likely due to improved fibronectin (Fn) deposition on the HA layer. Furthermore, the BG/2%PMB/HA surface enhanced cell survival and proliferation through crosstalk with integrin-mediated signaling pathways.

conclusionsPMB-coated BG effectively accelerates biomimetic mineralization and regulates cellular responses, making it a promising candidate for bone regeneration applications.

Indexed as

Biomimetic MaterialsBiomimeticsCalcification, PhysiologicCeramicsCoated Materials, BiocompatibleMethacrylatesPhosphorylcholineCell LineCell ProliferationHumansSpectroscopy, Fourier Transform InfraredBioglassCoated Materials, BiocompatibleMethacrylatesPhosphorylcholinepoly(2-methacryloyloxyethyl phosphorylcholine-co-n-butyl methacrylate)BioglassCell proliferationFocal adhesionPoly(2-methacryloxyethyl phosphorylcholine-co-butyl methacrylate)Surface modification

Identifiers

PMID41886255
PMCPMC13323433

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