ArticleJournal of echocardiography2026
Evaluation of the relationship between disease severity and echocardiographic parameters in Behçet's disease.
Article in Journal of echocardiography, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundBehçet’s disease is a multisystemic inflammatory disorder that may affect the cardiovascular system through mechanisms such as vasculitis, endothelial dysfunction, and microvascular ischemia. Although cardiac involvement is often subclinical, early detection is important for prognosis. Global longitudinal strain (GLS) has emerged as a sensitive tool for identifying subtle myocardial dysfunction. This study aimed to compare conventional and strain-based echocardiographic parameters between patients with Behçet’s disease and healthy controls, and to investigate the relationship between disease activity and myocardial strain.
methodsA total of 59 patients with Behçet’s disease and 58 age- and sex-matched healthy volunteers were included. Clinical activity was assessed using the Behçet’s Disease Current Activity Form (BDCAF). All participants underwent comprehensive transthoracic echocardiography, including tissue Doppler imaging and two-dimensional speckle-tracking analysis. Left ventricular (LV) and right ventricular (RV) GLS, MAPSE, TAPSE, MPI, diastolic parameters, and conventional chamber measurements were recorded. Correlation and multivariable linear regression analyses were performed to determine predictors of LV GLS.
resultsPatients with Behçet’s disease had significantly lower LV and RV GLS values compared with controls (LV GLS: −21.6 [IQR 18.4–24.5] vs. −21.7 [18.0–24.5], p = 0.001; RV GLS: −22.1 [19.0–27.2] vs. −22.8 [22.1–27.2], p = 0.001). MAPSE (1.7 [1.3–2.4] vs. 1.87 [1.2–3.0], p = 0.001), TAPSE (2.0 [1.3–2.9] vs. 2.16 [1.6–2.9], p = 0.001), and MPI (0.6 [0.3–1.0] vs. 0.7 [0.4–1.1], p = 0.049) were also significantly reduced in the Behçet group. Diastolic function parameters were impaired in the Behçet group, including a lower E/A ratio (1.0 [0.5–2.1] vs. 1.2 [0.7–1.8], p = 0.001) and prolonged isovolumic relaxation time (147.3 [74–289] ms vs. 117.2 [88–197] ms, p = 0.001). BDCAF scores showed a strong negative correlation with both LV GLS (r = − 0.56, p < 0.001) and RV GLS (r = − 0.64, p < 0.001). In multivariable linear regression analysis, the presence of Behçet’s disease (β = 0.618, p < 0.001), diabetes mellitus (β = −0.192, p = 0.009), and age (β = −0.228, p = 0.001) emerged as independent predictors of impaired LV GLS.
conclusionBehçet’s disease is associated with subclinical impairment of both LV and RV function despite preserved ejection fraction. GLS strongly correlates with disease activity, suggesting that inflammatory burden contributes to early myocardial dysfunction. Incorporating strain analysis into routine cardiac evaluation may improve early detection and risk stratification in Behçet’s disease.
Indexed as
Identifiers
41886242What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.