ArticleDigestive diseases and sciences2026
Effect of Vitamin C on the Prognosis of Patients with Acute Pancreatitis-Related Acute Kidney Injury Admitted to the Intensive Care Unit: A Retrospective Study.
Article in Digestive diseases and sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
Abstract
backgroundAcute kidney injury (AKI) is a common complication in patients with acute pancreatitis (AP) admitted to the intensive care unit (ICU). Vitamin C possesses anti-inflammatory and antioxidant properties that may benefit these patients. This study aimed to evaluate whether vitamin C administration improves the prognosis of patients with acute pancreatitis-related acute kidney injury (AP-AKI) in the ICU.
methodsWe conducted a retrospective cohort study using the Medical Information Mart for Intensive Care IV (MIMIC-IV) database. We included adult (≥ 18 years) patients with AP admitted to the ICU who were diagnosed with AKI (Stages 1-3) per the 2012 Kidney Disease: Improving Global Outcomes (KDIGO) guidelines within the onset of AP. Patients were divided into the vitamin C group (intravenous vitamin C administration after ICU admission) and the control group. Kaplan-Meier survival analysis, Cox proportional hazards regression model, and subgroup analysis were used to evaluate outcomes. Propensity score matching (PSM) was applied to reduce potential confounding factors. Finally, we investigated the effects of different doses of vitamin C on mortality.
resultA total of 959 patients were included in this study. After propensity score matching, 123 patients were allocated to the vitamin C group and 201 to the non-vitamin C group, with comparable baseline characteristics between the two groups. Our results showed that vitamin C treatment was associated with a reduced 30-day mortality in AP-AKI patients (hazard ratio [HR] = 0.40, 95% confidence interval [CI] 0.24-0.67). Subgroup analyses showed that the intervention effect of vitamin C was relatively consistent across most subgroups, whereas potential heterogeneity may exist among patients aged ≥ 65 years (P for interaction = 0.038) and those with myocardial infarction (P for interaction = 0.03). Further, no significant difference in 30-day mortality was observed among patients with AP-AKI treated with different doses of vitamin C (p = 0.27).
conclusionVitamin C administration after ICU admission was significantly associated with reduced 30-day mortality. Different vitamin C doses had no significant effect on the prognosis of AP-AKI.
Indexed as
Identifiers
41886237What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.