Evidence map›Paper›PMID 41886213›Full record

ArticleJournal of medical ultrasonics (2001)2026

Multicenter study of fetal crown-rump length measurement using 3D ultrasound in assisted reproductive technology pregnancies.

Ritsuko K Pooh, Megumi Machida, Kohtaro Uenishi, Takahito Miyake, Toshiyuki Hata, Rikikazu Sugiyama, Masahide Shiotani, Kenji Furui, Tetsunori Mukaida, Atsumi Yoshida and 4 more

Erratum issuedAbstract read
PubMed Publisher
In one paragraph

Article in Journal of medical ultrasonics (2001), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

14 authors.

Ritsuko K PoohFetal Brain Center, CRIFM Prenatal Medical Clinic, Matsushita Building 3F, 1-24, Uehonmachi 7, Tennoji, Osaka, 543-0001, Japan. ritsuko.pooh.brain@fetal-medicine-pooh.jp.ORCID http://orcid.org/0000-0002-1527-4595
Megumi MachidaFetal Brain Center, CRIFM Prenatal Medical Clinic, Matsushita Building 3F, 1-24, Uehonmachi 7, Tennoji, Osaka, 543-0001, Japan.
Kohtaro UenishiFetal Brain Center, CRIFM Prenatal Medical Clinic, Matsushita Building 3F, 1-24, Uehonmachi 7, Tennoji, Osaka, 543-0001, Japan.
Takahito MiyakeMiyake Clinic, Okayama, Japan.
Toshiyuki HataMiyake Clinic, Okayama, Japan.
Rikikazu SugiyamaSugiyama Clinic, Tokyo, Japan.
Masahide ShiotaniHanabusa Women's Clinic, Hyogo, Japan.
Kenji FuruiClinicMama, Gifu, Japan.
Tetsunori MukaidaHirishima HART Clinic, Hiroshima, Japan.
Atsumi YoshidaKiba Park Clinic, Tokyo, Japan.
Fumitoshi KogaKOGA FUMITOSHI WOMEN'S CLINIC, Fukuoka, Japan.
Motowo NabetaTsubaki Women's Clinic, Ehime, Japan.
Koichi KyonoKYONO ART CLINIC, Miyagi, Japan.
Yoshiharu MorimotoIVF JAPAN, Osaka, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeAccurate crown-rump length (CRL) measurement is fundamental for pregnancy dating and first-trimester screening. The Japanese standards established in 2003 using two-dimensional (2D) ultrasound require updating with modern imaging technology. This study aimed to establish new CRL reference standards for Japanese fetuses using three-dimensional (3D) ultrasound in precisely dated assisted reproductive technology (ART) pregnancies.

methodsWe conducted a multicenter retrospective cohort study of singleton ART pregnancies from 11 Japanese fertility centers (2020-2023), with pregnancy outcomes documented in 2024. Inclusion required term delivery (≥ 37 weeks) and birth weight within the mean ± 1.5 SD. CRL measurements were performed centrally using standardized 3D ultrasound protocols. Polynomial regression models were used to generate reference equations.

resultsOf 2,356 datasets, 1,598 pregnancies met the inclusion criteria. The mean maternal age was 36.3 ± 4.2 years. Reproducibility was excellent [intra- and inter-observer intraclass correlation coefficients (ICC) > 0.990]. No significant differences were found among ART methods in maternal age, gestational age at delivery, birth weight, or CRL growth pattern (p > 0.01). Third-degree polynomial regression produced reference curves for the 10th, 50th, and 90th percentiles. Compared with 2003 standards, CRL values were consistently larger (p < 0.001), and the growth trajectory showed no significant difference from the INTERGROWTH-21st international curve. Birth weights aligned with national standards, supporting general applicability.

conclusionThese updated 3D ultrasound-based CRL reference standards for ART pregnancies modernize Japanese practice and establish a refined framework for accurate gestational dating and first-trimester screening.

Indexed as

assisted reproductive technologycrown-rump lengthJapanese populationreference curvesthree-dimensional ultrasound

Identifiers

PMID41886213

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.