ArticleArchives of women's mental health2026
Maternal internalizing symptoms as a mechanism linking pre- and postnatal COVID-19 pandemic exposure with preschool-aged children's neurodevelopment.
Article in Archives of women's mental health, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
purposeThere is some evidence that children exposed to the COVID-19 pandemic experienced more neurodevelopmental difficulties than children before the pandemic, as well as evidence that women with young children experienced more mental health challenges during this period compared to pre-pandemic. However, it is unclear whether increased maternal mental health challenges acted as a mechanism linking pandemic exposure to children’s neurodevelopment difficulties.
methodsAs part of the Ontario Birth Study, women (N = 862) reported their internalizing (i.e., depression and anxiety) symptoms using the Patient Health Questionnaire-4 (PHQ-4) at three timepoints (prenatally and 8 and 24 months postnatally). Child neurodevelopment was assessed at 24 months using the Ages and Stages Questionnaire-3 (ASQ-3). Analyses included a combination of regression and path analyses with adjustment for covariates.
resultsWomen exposed to the pandemic prenatally and at 8 and 24 months postnatally reported more concurrent internalizing difficulties than those not exposed; however, women exposed both pre- and postnatally did not differ from those only exposed postnatally. Higher prenatal maternal internalizing symptoms were associated with lower child gross motor skills at 24 months. Higher maternal internalizing symptoms at 8 and 24 months were marginally (p < 0.1) associated with lower child personal-social and gross motor skills, respectively, at 24 months. The association between prenatal pandemic exposure and lower gross motor skills was marginally mediated by the presence of prenatal maternal internalizing symptoms.
conclusionMothers and young children may have been particularly vulnerable to pandemic stress. Maternal internalizing symptoms, especially during pregnancy, may serve as a pathway linking pandemic exposure with child neurodevelopment and may represent a malleable target for intervention.
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