Evidence map›Paper›PMID 41886085›Full record

ArticleEuropean journal of pediatrics2026

Frequency and short-term persistence of haematuria and/or proteinuria in neonates: a cohort study.

Jochen Kittel, Christine Seilbeck, Susanne Brandstetter, Michael Kabesch, Michael Melter, Angela Köninger, Christian Apfelbacher, Andreas Ambrosch, Tobias Geis

Abstract read
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Article in European journal of pediatrics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

9 authors.

Jochen KittelUniversity of Regensburg, Children's Hospital (KUNO), Hospital St. Hedwig of the Order of St. John, Regensburg, Germany. jochen.kittel@klinik.uni-regensburg.de.
Christine SeilbeckUniversity of Regensburg, Children's Hospital (KUNO), Hospital St. Hedwig of the Order of St. John, Regensburg, Germany.
Susanne BrandstetterUniversity of Regensburg, Children's Hospital (KUNO), Hospital St. Hedwig of the Order of St. John, Regensburg, Germany.
Michael KabeschUniversity of Regensburg, Children's Hospital (KUNO), Hospital St. Hedwig of the Order of St. John, Regensburg, Germany.
Michael MelterUniversity of Regensburg, Children's Hospital (KUNO), Hospital St. Hedwig of the Order of St. John, Regensburg, Germany.
Angela KöningerUniversity Clinic of Gynecology and Obstetrics, Hospital St. Hedwig of the Order of St. John, Regensburg, Germany.
Christian ApfelbacherInstitute of Social Medicine and Health Systems Research, Otto Von Guericke University Magdeburg, Magdeburg, Germany.
Andreas AmbroschInstitute for Laboratory medicine and Microbiology, Hospital of the Order of St. John, Regensburg, Germany.
Tobias GeisUniversity of Regensburg, Children's Hospital (KUNO), Hospital St. Hedwig of the Order of St. John, Regensburg, Germany.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeHaematuria and proteinuria may point to kidney diseases, but may also be found incidentally. Among schoolchildren, many studies suggest their prevalence to around 1%. In neonates, the frequency and persistence of haematuria and/or proteinuria in the general population have so far not been investigated systematically.

methodsIn the course of the prospective KUNO-Kids Health Study, urine samples were collected and analysed by dipstick in asymptomatic neonates on days three to five after birth. Those with positive findings underwent a maximum of two follow-ups until 16 weeks of age and factors associated with haematuria and/or proteinuria were explored.

resultsOf 509 participants with a urine sample available, 27% (n = 139) exhibited positive results. Of these, 58% (n = 81) had isolated haematuria, 21% (n = 29) had isolated proteinuria, and 21% (n = 29) had both. Of all children with positive urine tests, 76% (n = 105) underwent a first follow-up (mean 7 weeks later), and only in 1.9% (n = 2) was a positive result found. In the second follow-up (mean 2 weeks later), no positive results were detected anymore. Positive urine test results were more common in females and after vaginal delivery (p < 0.001 and p = 0.037, respectively).

conclusionThe present study identified haematuria and/or proteinuria in a significant proportion of healthy newborns shortly after birth, but results returned to normal within weeks in all participants available for follow- up. Thus, isolated findings of haematuria and/or proteinuria in newborns should be interpreted with caution. WHAT IS KNOWN: • Previous studies have reported the prevalence and persistence of haematuria and/or proteinuria in school- age children, but data on haematuria and/or proteinuria in neonates are scarce. WHAT IS NEW: • Positive urinary test results for haematuria and/or proteinuria are common after birth and were found in 27%. • Positive urinary test results returned to normal within 16 weeks in all children tested.

Indexed as

HematuriaProteinuriaFemaleFollow-Up StudiesHumansInfant, NewbornMalePrevalenceProspective StudiesUrinalysisBirth cohortHaematuriaKidney diseaseNewbornProteinuriaUrine test

Identifiers

PMID41886085
PMCPMC13021806

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.