ArticleArchives of virology2026
Exploring ASFV tolerance in Indian pigs: A genetic and relative expression study of the STING1 gene.
Article in Archives of virology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
- Current Insights into the Epidemiology and Transmission Dynamics of African Swine Fever Virus and Future Control Perspectives.Pathogens (Basel, Switzerland) · 2026Review
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Authors and funding
11 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
African Swine Fever (ASF) causes severe economic losses in the global pig industry, characterized by high mortality rates and lack of an effective vaccine. Interestingly, India's indigenous Doom pig breed has displayed tolerance to ASF, remaining seropositive without detectable viremia. This study investigated the genetic basis of ASFV tolerance, focusing on the STING1 gene, a key component of the cGAS-STING antiviral signaling pathway. In-silico docking identified a potential ASFV protein binding site within exon 5 of STING1. A non-synonymous SNP (CGG/TGG; R→W) at position 148 in this region was selected for genotyping. We genotyped 119 pigs, representing tolerant (Doom), susceptible, and ASFV-infected groups, using allele-specific PCR and Sanger sequencing. Doom pigs and most other breeds, including ASFV-infected samples, displayed a conserved GG genotype. Susceptible Manipuri Black and Ghoongroo pigs, however, displayed both AA and GG genotypes, yet still succumbed to the disease. A significant downregulation (0.436-fold) of STING1 was observed in ASFV-infected spleen tissue, indicating active immune evasion by the virus. The lack of a unique allele in Doom pigs compared to susceptible breeds indicates that ASFV tolerance is unlikely to be associated with this STING1 SNP. Therefore, genome-wide studies are recommended to identify markers truly associated with ASFV tolerance in this resilient breed.
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