Evidence map›Paper›PMID 41885960›Full record

ArticleClinical research in cardiology : official journal of the German Cardiac Society2026

STEMI caused by spontaneous coronary artery dissection: prevalence, patient characteristics and outcomes.

Stefan Malleier, Luise Gaede, Susanne Jung, Mohamed Marwan, Stephan Achenbach, Monique Tröbs

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Article in Clinical research in cardiology : official journal of the German Cardiac Society, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

6 authors.

Stefan MalleierDepartment of Cardiology, University Hospital Erlangen, Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU), Ulmenweg 18, 91054, Erlangen, Germany. s-malleier@hotmail.de.ORCID http://orcid.org/0009-0002-3337-5215
Luise GaedeDepartment of Cardiology, University Hospital Erlangen, Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU), Ulmenweg 18, 91054, Erlangen, Germany.ORCID http://orcid.org/0000-0002-9678-908X
Susanne JungDepartment of Cardiology, University Hospital Erlangen, Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU), Ulmenweg 18, 91054, Erlangen, Germany.ORCID http://orcid.org/0000-0002-4031-6304
Mohamed MarwanDepartment of Cardiology, University Hospital Erlangen, Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU), Ulmenweg 18, 91054, Erlangen, Germany.ORCID http://orcid.org/0000-0001-8759-4101
Stephan AchenbachDepartment of Cardiology, University Hospital Erlangen, Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU), Ulmenweg 18, 91054, Erlangen, Germany.ORCID http://orcid.org/0000-0002-7596-095X
Monique TröbsDepartment of Cardiology, University Hospital Erlangen, Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU), Ulmenweg 18, 91054, Erlangen, Germany.ORCID http://orcid.org/0000-0002-5661-1017

Funding

State of Bavaria ER-MIKKIState of Bavaria LSM-2007-0002
6 · The paper itself

Abstract

backgroundSpontaneous coronary artery dissection (SCAD) is a rare, but increasingly recognised cause of myocardial infarction. Our aim was to provide comprehensive real-world data on the prevalence of SCAD among patients who present with ST-segment elevation myocardial infarction (STEMI).

methodsRetrospective analysis of medical records and review of coronary angiograms allowed identification of all SCAD cases in a cohort of consecutive patients with STEMI, and review of clinical data provided further characterisation.

resultsAmong 2707 consecutive STEMI patients, the prevalence of SCAD was 0.9% (n = 24). In 9 cases, the diagnosis of SCAD diagnosis had been missed during clinical routine (37.5%). Compared to non-SCAD-STEMI, SCAD patients were younger (median age 53.5 vs. 66.0 years, p = 0.001) and more likely to be female (75.0% vs. 29.7%, p < 0.001). The most common symptom was typical angina (chest pain limited to the thorax, 75%). Importantly, six patients (25%) experienced cardiac arrest, either as the presenting symptom before (n = 2) or after first medical contact (n = 3), or during hospitalisation (n = 1). The most common angiographic pattern was SCAD type 4 (complete vessel occlusion, 37.5%), followed by type 2a (29.2%) and 2b (25%). Intravascular imaging was used in 25% (n = 6). 58.3% of patients with SCAD-STEMI underwent percutaneous coronary intervention (PCI). Complications occurred in 50% of PCI, mostly due to propagation of intramural hematoma. All patients survived to hospital discharge. Long-term follow-up was available in 50% of patients. While event rate was low, recurrence of SCAD did occur, in some cases after several years.

conclusionIn a Western European cohort of STEMI patients, SCAD was the underlying cause in approximately 1% of all cases. The true incidence may be higher since cardiac arrest occurred in one quarter of all patients within the cohort. Interventional treatment, while often required in SCAD-STEMI, is fraught by a high complication rate.

Indexed as

Coronary Vessel AnomaliesST Elevation Myocardial InfarctionVascular DiseasesAgedCoronary AngiographyDissection, Blood VesselElectrocardiographyFemaleFollow-Up StudiesGermanyHumansMaleMiddle AgedPrevalenceRetrospective StudiesRisk FactorsCoronary angiographySCADSpontaneous coronary artery dissectionST-elevation myocardial infarctionSTEMI

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.