ArticleHealth psychology : official journal of the Division of Health Psychology, American Psychological Association2026
Negative affect and peripheral inflammation: The role of cognitive reappraisal and expressive suppression.
Article in Health psychology : official journal of the Division of Health Psychology, American Psychological Association, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
The association between global negative affect and inflammation is inconsistently observed in healthy, community samples.
objectivesIdentifying person-level characteristics that influence this association may help clarify how negative affect confers risk of morbidity and mortality and which individuals may benefit from early intervention. One such characteristic that may influence the negative affect-inflammation association includes the use of emotion regulation strategies. Here, we examined whether regular use of emotion regulation strategies, namely reappraisal and suppression, moderated the association between global negative affect and peripheral inflammation.
methodProinflammatory biomarkers (interleukin-6 [IL-6] and C-reactive protein) and self-reported negative affect and emotion regulation usage were assessed at the baseline visit of three study cohorts completed between 2008 and 2021. Age, sex, body mass index, and education were included as covariates in multiple regression models.
resultsIn a healthy sample of midlife adults (
conclusionsFindings suggest that, among otherwise healthy adults, the more frequent-and possibly contextually invariant-use of suppression or reappraisal may partly influence the variable coupling between negative affect and IL-6. (PsycInfo Database Record (c) 2026 APA, all rights reserved).
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