SynthesisHealth psychology : official journal of the Division of Health Psychology, American Psychological Association2026
Dimensions of early life adversity and cardiometabolic health in adulthood: A systematic review and meta-analysis.
Synthesis in Health psychology : official journal of the Division of Health Psychology, American Psychological Association, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- Glucose as fuel for HPA axis regulation: A narrative review on energy metabolism, stress reactivity, and early life adversity.Comprehensive psychoneuroendocrinology · 2026Review
- Early life adversity and physical health implications in adulthood: The Multi-Ethnic Study of Atherosclerosis.Psychoneuroendocrinology · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors.
Funding
Abstract
objectiveEarly life adversity (ELA) has been associated with increased cardiometabolic disease risk in adulthood. This systematic review and meta-analysis evaluated whether cardiometabolic health outcomes differ based on adversity type (threat, deprivation, or cumulative exposure) and assessed the moderating role of sex and race.
methodA comprehensive search of PsycINFO, PubMed, and Web of Science identified 90 studies (82 independent samples) reporting associations between ELA and cardiometabolic outcomes in adults. Inclusion criteria required peer-reviewed, empirical studies linking ELA to disease biomarkers (e.g., cholesterol, hypertension, and atherosclerosis) and health events (e.g., cardiovascular disease, stroke, and diabetes). Random-effects meta-analyses were conducted using Comprehensive Meta-Analysis version 4. Publication bias and study heterogeneity were evaluated using Egger's tests and trim-and-fill procedures.
resultsResults indicated that greater exposure to ELA, aggregated across all forms, was associated with increased total cardiometabolic health problems (
conclusionsFindings underscore the importance of cumulative ELA as a correlate of adult cardiometabolic health, while also highlighting emerging evidence for differential effects of cumulative adversity compared with threat and deprivation. Results highlight the potential value of comprehensive adversity assessment for identifying at-risk populations and for guiding mechanistic and preventive research. (PsycInfo Database Record (c) 2026 APA, all rights reserved).
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.