Evidence map›Paper›PMID 41885885›Full record

ArticleHealth psychology : official journal of the Division of Health Psychology, American Psychological Association2026

Mediators of attachment, frailty, and mild cognitive impairment in older adults.

Erik J Buchholz, Chandra A Reynolds, Tyler R Bell, McKenna E Williams, Rongxiang Tang, Matthew S Panizzon, Michael J Lyons, Amy J Jak, Jack F V Hunt, Nathan A Gillespie and 4 more

Abstract readTwin Study
In one paragraph

Article in Health psychology : official journal of the Division of Health Psychology, American Psychological Association, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Erik J BuchholzDepartment of Psychiatry, University of California San Diego.ORCID 0000-0003-0474-4384
Chandra A ReynoldsInstitute for Behavioral Genetics, University of Colorado Boulder.
Tyler R BellDepartment of Psychiatry, University of California San Diego.
McKenna E WilliamsDepartment of Psychiatry, University of California San Diego.
Rongxiang TangDepartment of Psychological & Brain Sciences, Texas A&M University.
Matthew S PanizzonDepartment of Psychiatry, University of California San Diego.ORCID 0000-0002-6449-2097
Michael J LyonsDepartment of Psychological and Brain Sciences, Boston University.
Amy J JakDepartment of Psychiatry, University of California San Diego.
Jack F V HuntDepartment of Psychiatry, University of California San Diego.
Nathan A GillespieVirginia Institute for Psychiatric and Behavior Genetics, Virginia Commonwealth University.
Christine Fennema-NotestineDepartment of Psychiatry, University of California San Diego.ORCID 0000-0002-6527-6361
Jeremy A ElmanDepartment of Psychiatry, University of California San Diego.
William S KremenDepartment of Psychiatry, University of California San Diego.
Carol E FranzDepartment of Psychiatry, University of California San Diego.

Funding

The VETSA Longitudinal Twin Study of Cognition and Aging (VETSA 4)R01AG050595 · NIA · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI ELMAN, JEREMY A, FRANZ, CAROL ELAINE · 2015 to 2024
$28.0M
Urban Air Pollution and Pathological Brain Aging: A Nationwide Twin Study in MenP01AG055367 · NIA · UNIVERSITY OF SOUTHERN CALIFORNIA · PI CHEN, JIU-CHIUAN · 2018 to 2022
$11.5M
The VETSA Longitudinal MRI Twin Study of Aging (VETSA MRI 4)R01AG076838 · NIA · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI ANDERS M DALE, Jeremy A Elman · 2022 to 2026
$8.7M
Genetic Predictors, Transcriptomic Biomarkers, & Neurobiological Signatures of Resilience to Alzheimer's DiseaseR01AG064955 · NIA · UPSTATE MEDICAL UNIVERSITY · PI FENNEMA-NOTESTINE, CHRISTINE, GLATT, STEPHEN J · 2019 to 2023
$3.8M
Gene-Environment Interplay of Social Contexts and Aging-Related OutcomesR01AG037985 · NIA · UNIVERSITY OF SOUTHERN CALIFORNIA · PI PEDERSEN, NANCY L · 2010 to 2014
$3.2M
Linking genetic subtypes of Alzheimer's disease to biological and cognitive heterogeneityK01AG063805 · NIA · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI ELMAN, JEREMY A · 2021 to 2024
$516k
National Institutes of Health; National Institute on AgingNIA NIH HHS K01 AG063805NIA NIH HHS P01 AG055367NIA NIH HHS R01 AG037985NIA NIH HHS R01 AG050595NIA NIH HHS R01 AG064955NIA NIH HHS R01 AG076838
6 · The paper itself

Abstract

objectivePoor social relations of older adults have been linked to cognitive decline, dementia risk, morbidity, and mortality. We investigated how characteristic ways people relate to romantic partners (adult attachment) might function as risk/protective factors for overall health or dementia risk. Specifically, we evaluated whether attachment anxiety and/or attachment avoidance at midlife predicted cumulative deficit frailty (CDF) and mild cognitive impairment (MCI) in early old age.

methodParticipants were 1,608 men in the Vietnam Era Twin Study of Aging. Participants' attachment was assessed at a mean age of 56 (starting 2003) and health mediators at a mean age of 62 (2009-2014; e.g., perceived stress, doctor visits, smoking, alcohol consumption, and social isolation). Outcomes at a mean age of 68 (2016-2019) included CDF based on a 37-item scale and MCI. Structural equation modeling assessed associations between attachment, mediators, and outcomes.

resultsThe effect of attachment anxiety on CDF was indirect, mediated by perceived stress, doctor visits, and smoking at age 62 (total indirect effect: β = .147,

conclusionsAttachment anxiety and attachment avoidance predict frailty and cognitive function through different pathways in older adults. Viewing others as trustworthy and dependable in midlife may be protective against frailty and dementia risk in old age. Focusing on improving the quality of interpersonal relationships may thus help to reduce risk. (PsycInfo Database Record (c) 2026 APA, all rights reserved).

Indexed as

AgingAnxietyCognitive DysfunctionFrailtyInterpersonal RelationsObject AttachmentSexual PartnersAgedHumansMaleMiddle AgedStress, PsychologicalSubjective Stress

Identifiers

PMID41885885
PMCPMC13122343

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.