Evidence map›Paper›PMID 41885872›Full record

ArticleJAMA otolaryngology-- head & neck surgery2026

Dysfunction in Olfactory Identification and Physical Function Decline in Older Adults.

Yulu Pan, Honglei Chen, Yaqun Yuan, Jayant M Pinto, David Couper, Thomas H Mosley, Srishti Shrestha, Nicholas R Rowan, Anna Kucharska-Newton

Abstract read
In one paragraph

Article in JAMA otolaryngology-- head & neck surgery, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Olfactory Decline in Elderly at High Altitudes: A Narrative Review.International journal of general medicine · 2026
    Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors.

Yulu PanGillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill.
Honglei ChenDepartment of Epidemiology and Biostatistics, College of Human Medicine, Michigan State University, East Lansing.
Yaqun YuanDepartment of Epidemiology and Biostatistics, College of Human Medicine, Michigan State University, East Lansing.
Jayant M PintoSection of Otolaryngology-Head and Neck Surgery, The University of Chicago, Chicago, Illinois.
David CouperGillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill.
Thomas H MosleyThe Memory Impairment and Neurodegenerative Dementia Center, University of Mississippi Medical Center, Jackson.
Srishti ShresthaThe Memory Impairment and Neurodegenerative Dementia Center, University of Mississippi Medical Center, Jackson.
Nicholas R RowanDepartment of Otolaryngology-Head and Neck Surgery, The Johns Hopkins University School of Medicine, Baltimore, Maryland.
Anna Kucharska-NewtonGillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill.

Funding

Poor sense of smell and the health of older adultsR01AG071517 · NIA · MICHIGAN STATE UNIVERSITY · PI HONGLEI CHEN · 2022 to 2026
$2.7M
NIA NIH HHS R01 AG071517
6 · The paper itself

Abstract

Importance: Few longitudinal studies have examined the association of olfactory dysfunction with future decline in physical function. Objective: To examine cross-sectional and longitudinal associations between olfaction and physical function among older adults (age ≥65 years). Design, Setting, and Participants: This cohort study used data from the Atherosclerosis Risk in Communities (ARIC) study, a prospective cohort study that enrolled 15 792 adults aged 45 to 64 years from 4 US communities. In the present study, we used data from visits 5 (2011-2013), 6 (2016-2017), and 7 (2018-2019). Data were analyzed July 16, 2025. Exposure: Olfaction was measured using the 12-item Sniffin' Sticks Odor Identification Test (total score range, 0-12) at visit 5 and categorized as good (11-12 [reference]), moderate (9-10), and poor (0-8). Main Outcomes and Measures: Physical function was assessed using the Short Physical Performance Battery (SPPB) overall score (range, 0-12); SPPB subscale scores (range, 0-4) for balance, 4-m usual pace walk, and chair stand; and gait speed at visits 5 (baseline), 6, and 7. Grip strength was assessed at visits 5 and 7. Results: In the analytic sample of 5474 participants (mean [SD] age, 75.3 [5.0] years; 3163 [57.8%] female), the estimated mean difference in total SPPB scores was -0.14 (95% CI, -0.28 to -0.01) among those with moderate vs good olfaction and -0.49 (95% CI, -0.63 to -0.35) among those with poor vs good olfaction. In longitudinal analyses, compared with participants with good olfaction, the estimated mean annual difference in SPPB score was -0.05 (95% CI, 0.08 to -0.02) among those with moderate olfaction and -0.11 (95% CI, -0.14 to -0.08) among those with poor olfaction. Consistent trends were observed across SPPB subscales (eg, balance score: estimated mean difference in poor vs good olfaction, -0.18 [95% CI, -0.02 to -0.12]), gait speed (-0.06 [95% CI, -0.07 to -0.04] m/s), and grip strength (-1.50 [95% CI, -1.98 to -1.01] kg). Conclusions and Relevance: In this cohort study, poor olfaction in older adults was associated with a decline in physical functioning. These findings may have clinical implications for identifying older adults at elevated risk. Future research should investigate biologic mechanisms linking olfactory dysfunction with functional aging.

Indexed as

Olfaction DisordersPhysical Functional PerformanceAgedCross-Sectional StudiesFemaleHumansLongitudinal StudiesMaleMiddle AgedPostural BalanceProspective Studies

Identifiers

PMID41885872
PMCPMC13022770

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.