Article in The Journal of experimental medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registry
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
5 · Who and what money
Authors and funding
24 authors.
Julie BexCentre de Recherche sur l'Inflammation, Institut National de la Santé et de la Recherche Médicale (INSERM) UMR1149, Centre National de la Recherche Scientifique (CNRS) EMR8252, Faculté de Médecine Site Bichat, Université Paris Cité, Laboratoire d'Excellence Inflamex, Paris, France.ORCID 0009-0000-3985-6410
Victoria PeterCentre de Recherche sur l'Inflammation, Institut National de la Santé et de la Recherche Médicale (INSERM) UMR1149, Centre National de la Recherche Scientifique (CNRS) EMR8252, Faculté de Médecine Site Bichat, Université Paris Cité, Laboratoire d'Excellence Inflamex, Paris, France.ORCID 0009-0004-9256-9831
Chaimae SajiCentre de Recherche sur l'Inflammation, Institut National de la Santé et de la Recherche Médicale (INSERM) UMR1149, Centre National de la Recherche Scientifique (CNRS) EMR8252, Faculté de Médecine Site Bichat, Université Paris Cité, Laboratoire d'Excellence Inflamex, Paris, France.ORCID 0009-0008-9999-4880
Claire DupontCNRS UMR 5070, INSERM U1301, Etablissement Français du Sang, Ecole Nationale Vetérinaire de Toulouse, Institut RESTORE, Université de Toulouse , Toulouse, France.ORCID 0000-0002-8492-4985
Mathilde LavernheCNRS UMR 5070, INSERM U1301, Etablissement Français du Sang, Ecole Nationale Vetérinaire de Toulouse, Institut RESTORE, Université de Toulouse , Toulouse, France.ORCID 0009-0003-0169-3777
Suoqin JinSchool of Mathematics and Statistics, Wuhan University , Wuhan, China.ORCID 0000-0002-5131-0215
Léa ChapartCentre de Recherche sur l'Inflammation, Institut National de la Santé et de la Recherche Médicale (INSERM) UMR1149, Centre National de la Recherche Scientifique (CNRS) EMR8252, Faculté de Médecine Site Bichat, Université Paris Cité, Laboratoire d'Excellence Inflamex, Paris, France.ORCID 0009-0008-9720-1146
Gregory GautierCentre de Recherche sur l'Inflammation, Institut National de la Santé et de la Recherche Médicale (INSERM) UMR1149, Centre National de la Recherche Scientifique (CNRS) EMR8252, Faculté de Médecine Site Bichat, Université Paris Cité, Laboratoire d'Excellence Inflamex, Paris, France.ORCID 0000-0003-4887-5095
Olivier ThibaudeauINSERM UMS34, Plateforme de Morphologie HIPNO, Université Paris Cité , Paris, France.ORCID 0009-0000-5927-3677
Morgane K ThaminyCentre de Recherche sur l'Inflammation, Institut National de la Santé et de la Recherche Médicale (INSERM) UMR1149, Centre National de la Recherche Scientifique (CNRS) EMR8252, Faculté de Médecine Site Bichat, Université Paris Cité, Laboratoire d'Excellence Inflamex, Paris, France.ORCID 0009-0002-4842-0277
John TchenCentre de Recherche sur l'Inflammation, Institut National de la Santé et de la Recherche Médicale (INSERM) UMR1149, Centre National de la Recherche Scientifique (CNRS) EMR8252, Faculté de Médecine Site Bichat, Université Paris Cité, Laboratoire d'Excellence Inflamex, Paris, France.ORCID 0000-0001-6474-6790
Quentin SimonCentre de Recherche sur l'Inflammation, Institut National de la Santé et de la Recherche Médicale (INSERM) UMR1149, Centre National de la Recherche Scientifique (CNRS) EMR8252, Faculté de Médecine Site Bichat, Université Paris Cité, Laboratoire d'Excellence Inflamex, Paris, France.ORCID 0000-0002-2383-2809
Xing DaiDepartment of Biological Chemistry, School of Medicine, University of California, Irvine, CA, USA.ORCID 0000-0001-8134-1365
Kensuke MiyakeInstitute of Integrated Research, Institute of Science Tokyo , Tokyo, Japan.ORCID 0000-0003-1149-3755
Hajime KarasuyamaInstitute of Integrated Research, Institute of Science Tokyo , Tokyo, Japan.ORCID 0000-0003-0689-0836
Jean X JiangDepartment of Biochemistry and Structural Biology, University of Texas Health Science Center, San Antonio, TX, USA.ORCID 0000-0002-2185-5716
Karmella NaidooMalaghan Institute of Medical Research, Victoria University , Wellington, New Zealand.ORCID 0000-0002-2505-5222
Marc BenhamouCentre de Recherche sur l'Inflammation, Institut National de la Santé et de la Recherche Médicale (INSERM) UMR1149, Centre National de la Recherche Scientifique (CNRS) EMR8252, Faculté de Médecine Site Bichat, Université Paris Cité, Laboratoire d'Excellence Inflamex, Paris, France.ORCID 0000-0001-7763-3795
Ulrich BlankCentre de Recherche sur l'Inflammation, Institut National de la Santé et de la Recherche Médicale (INSERM) UMR1149, Centre National de la Recherche Scientifique (CNRS) EMR8252, Faculté de Médecine Site Bichat, Université Paris Cité, Laboratoire d'Excellence Inflamex, Paris, France.ORCID 0000-0002-2661-2983
Renato C MonteiroCentre de Recherche sur l'Inflammation, Institut National de la Santé et de la Recherche Médicale (INSERM) UMR1149, Centre National de la Recherche Scientifique (CNRS) EMR8252, Faculté de Médecine Site Bichat, Université Paris Cité, Laboratoire d'Excellence Inflamex, Paris, France.ORCID 0000-0001-5202-5646
Graham Le GrosMalaghan Institute of Medical Research, Victoria University , Wellington, New Zealand.ORCID 0000-0002-5721-0442
Agnès CosteCNRS UMR 5070, INSERM U1301, Etablissement Français du Sang, Ecole Nationale Vetérinaire de Toulouse, Institut RESTORE, Université de Toulouse , Toulouse, France.ORCID 0000-0001-7781-3323
Nicolas CharlesCentre de Recherche sur l'Inflammation, Institut National de la Santé et de la Recherche Médicale (INSERM) UMR1149, Centre National de la Recherche Scientifique (CNRS) EMR8252, Faculté de Médecine Site Bichat, Université Paris Cité, Laboratoire d'Excellence Inflamex, Paris, France.ORCID 0000-0002-5416-5834
Christophe PellefiguesCentre de Recherche sur l'Inflammation, Institut National de la Santé et de la Recherche Médicale (INSERM) UMR1149, Centre National de la Recherche Scientifique (CNRS) EMR8252, Faculté de Médecine Site Bichat, Université Paris Cité, Laboratoire d'Excellence Inflamex, Paris, France.ORCID 0000-0001-7036-0763
Funding
CSF-1 Gene Expression in Osteoclast BiologyR01AG045040 · NIA · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI JIANG, JEAN X · 2013 to 2017
$1.5M
Agence Nationale de la Recherche ANR-19-CE17-0029Agence Nationale de la Recherche ANRPIA-10-LABX-0017Centre National de la Recherche ScientifiqueFondation pour la Recherche Médicale EQU201903007794Health Research Council of New ZealandInstitut National de la Santé et de la Recherche MédicaleMarjorie Barclay TrustNational Natural Science Foundation of China 92374108NIA NIH HHS R01 AG045040NIH HHS R01 AG045040Université de Paris
6 · The paper itself
Abstract
An active resolution is critical to control the duration of inflammation and limit its pathological consequences. Defects in resolution during wound healing allow the emergence of chronic wounds, a common complication in the elderly. Here, we show that basophils accumulate in perivascular areas at the periphery of mouse skin wounds for at least 3 wk, during both the inflammation and resolution phases of wound healing. Depletion of basophils induces an increased secretion of inflammatory molecules, accumulation and activation of pro-inflammatory leukocytes, and delays the wound healing response. Basophils particularly promote epidermal differentiation towards homeostasis. These properties are particularly driven by basophil-derived IL-4. Unexpectedly, aged mice basophils more potently infiltrate skin wounds to promote inflammation resolution. Thus, basophils are pro-resolution cells during an essential biological process such as skin wound healing. Unraveling basophil pro-resolution properties may reveal new strategies to fight chronic wounds in the elderly.
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.
Basophils drive the resolution and promote wound healing in adult and aged mice. · full record | OpenQuestion