Evidence map›Paper›PMID 41885735›Full record

ArticlePhysiological reports2026

Synephrine potentiates lidocaine-induced cutaneous analgesia via α-adrenergic receptors in male rats.

An-Kuo Chou, Chong-Chi Chiu, Kuo-Sheng Liu, Yu-Wen Chen, Ching-Hsia Hung, Jhi-Joung Wang

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Physiological reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

An-Kuo ChouDepartment of Anesthesiology, China Medical University Hospital, Taichung, Taiwan.
Chong-Chi ChiuDepartment of General Surgery & Department of Medical Education and Research, E-Da Cancer Hospital, I-Shou University, Kaohsiung, Taiwan.
Kuo-Sheng LiuDepartment of Pharmacy, Chia Nan University of Pharmacy and Science, Tainan, Taiwan.
Yu-Wen ChenDepartment of Medical Research, Chi Mei Medical Center, Tainan, Taiwan.
Ching-Hsia HungDepartment of Physical Therapy, College of Medicine, National Cheng Kung University, Tainan, Taiwan.ORCID 0000-0001-6316-4342
Jhi-Joung WangDepartment of Medical Research, Chi Mei Medical Center, Tainan, Taiwan.

Funding

China Medical University, Taiwan (CMU) CMU114-MF-113I-Shou University (ISU) NCKUEDA11407National Science and Technology Council (Taiwan) NSTC 114-2314-B-039-038-MY2National Science and Technology Council (Taiwan) NSTC 114-2314-B-039-047-
6 · The paper itself

Abstract

This study aimed to assess the cutaneous analgesic effect of the lidocaine-synephrine combination and its underlying α-adrenergic receptor-mediated mechanism in comparison with phenylephrine. Cutaneous analgesia after subcutaneous drug injection was assessed by inhibition of the cutaneous trunci muscle reflex in response to needle pinpricks on the shaved dorsal skin of Sprague-Dawley rats. Synephrine, like the local anesthetic lidocaine, is capable of inducing cutaneous analgesia but is less potent. On an equipotent basis (ED

Indexed as

AnalgesicsAnesthetics, LocalLidocaineReceptors, Adrenergic, alphaSynephrineAnalgesiaAnimalsDose-Response Relationship, DrugDrug SynergismMalePhenylephrineRatsRats, Sprague-DawleySkinAnalgesicsAnesthetics, LocalLidocainePhenylephrineReceptors, Adrenergic, alphaSynephrineinfiltrative cutaneous analgesiaisobologramsphentolaminephenylephrinesynephrine

Identifiers

PMID41885735
PMCPMC13097421

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.