ArticleMediators of inflammation2026
Anti-Inflammatory Effects of Stachys pilifera Extracts in LPS-Stimulated RAW264.7 Macrophages.
Article in Mediators of inflammation, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
2 citing papers in PubMed.
- Anti-inflammatory, analgesic, and anti-immune-mediated polyarthritis activities of topically applied polarity fractions ofFrontiers in veterinary science · 2026Article
- Anti-Inflammatory Effects of Stachys pilifera Extracts in LPS-Stimulated RAW264.7 Macrophages.Mediators of inflammation · 2026Article
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
objectiveInflammation is a fundamental biological response that serves to protect the body from physical damage and harmful stimuli. However, chronic inflammation is implicated in the pathogenesis of various inflammatory diseases. Stachys pilifera Benth. has been traditionally used for its anti-inflammatory properties, yet its precise mechanisms of action remain to be fully elucidated. This study aims to investigate the effects of S. pilifera Benth. extract and its fractions on lipopolysaccharide (LPS)-induced inflammatory responses in RAW264.7 macrophage cells. METHODOLOGY: The anti-inflammatory potential of the methanolic extract and its ethyl acetate, butanol, and water fractions were evaluated by assessing their inhibitory effects on nitric oxide (NO) and prostaglandin E2 (PGE
resultsThe methanolic extract, ethyl acetate fraction, and butanol fraction significantly reduced the production of NO and PGE
conclusionBy downregulating NF-κB activity, S. pilifera Benth. effectively modulates the expression of key proinflammatory mediators, including inducible NO synthase (iNOS) and COX-2, ultimately leading to reduced NO and PGE
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Registered trials
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