Trial reportExperimental physiology2026
Influence of low-dose dopamine on exercise in fibrosing interstitial lung disease.
Trial report in Experimental physiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Influence of low-dose dopamine on exercise in fibrosing interstitial lung disease.Experimental physiology · 2026Trial
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
Abstract
Fibrotic interstitial lung disease (FILD) is associated with dyspnoea and exercise intolerance. In other cardiorespiratory conditions, heightened carotid body (CB) chemoreflex sensitivity is associated with reduced exercise capacity. We tested the hypothesis that CB chemoreflex inhibition would improve exercise endurance time (EET) and reduce dyspnoea in FILD. In this randomised, single-blind study, 10 FILD patients (four women, 64 ± 8 years) completed the experimental procedures. Low-dose dopamine infusion (2 µg/kg/min) was used to inhibit the CB chemoreflex, and its effectiveness verified by measuring the hypoxic ventilatory response. Participants performed two constant work rate cycle exercise tests (75% of peak work rate) to exhaustion with either dopamine or saline as control. Dopamine suppressed the CB chemoreflex sensitivity in seven of the ten participants. Overall, dopamine reduced chemoreflex sensitivity by 27% relative to control (-0.646 ± 0.344 vs. -0.472 ± 0.410 L/min/%, P = 0.103). EET (saline 460 ± 411 s vs. dopamine 363 ± 182 s, P = 0.305) and exertional dyspnoea scores were similar between the conditions. Among those displaying reduced CB sensitivity with dopamine, there was a positive correlation between the magnitude of reduction in sensitivity and improvement in EET (r
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.