ReviewExperimental physiology2026
The principles of systems biology.
Review in Experimental physiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- How physiology solves the gene-centric impasse.Experimental physiology · 2026Review
- The principles of systems biology.Experimental physiology · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Physiological interpretations of Systems Biology have made many advances since the Principles of Systems Biology were first published in this journal in 2008. Those advances show that the main principle, Biological Relativity, is a logical necessity since no system can exist without the form of the system. That form creates the necessary boundary conditions for the integration of any equations for the mechanics by which the elements of the system interact. A further conclusion is that the Central Dogma of molecular biology is an incomplete representation of causation in biology. It neglects the multi-scale properties of living systems, and its assumption that DNA can self-replicate accurately enough is incorrect. The replicator cannot therefore be separate from its vehicle, the living cell. This failure has led to a gene-centric impasse: the failure of genomics to produce the expected cures for common fatal diseases. Physiology now needs to provide alternative ways in which this problem can be successfully addressed.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.