Evidence map›Paper›PMID 41885373›Full record

ArticleeLife2026

Age-dependent H3K9 trimethylation by dSetdb1 impairs mitochondrial UPR leading to degeneration of olfactory neurons and loss of olfactory function in

Francisco Muñoz-Carvajal, Nicole Sanhueza, Mario Sanhueza, Felipe A Court

Abstract read
In one paragraph

Article in eLife, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Francisco Muñoz-CarvajalCenter for Integrative Biology, Faculty of Sciences, Universidad Mayor, Santiago, Chile.ORCID https://orcid.org/0009-0003-6650-0374
Nicole SanhuezaCenter for Integrative Biology, Faculty of Sciences, Universidad Mayor, Santiago, Chile.ORCID https://orcid.org/0009-0001-5173-0471
Mario SanhuezaCenter for Integrative Biology, Faculty of Sciences, Universidad Mayor, Santiago, Chile.ORCID https://orcid.org/0000-0002-0125-0154
Felipe A CourtCenter for Aging Research and Healthy Longevity, Faculty of Sciences, Universidad Mayor, Santiago, Chile.ORCID https://orcid.org/0000-0002-9394-7601

Funding

ANID Fondo Subvencion a la Instalacion Academia PAI77180059Financiamiento Basal para Centros Científicos y Tecnológicos de Excelencia Centro Ciencia and Vida FB210008Fondo de Financiamiento de Centros de Investigación en Áreas Prioritarias 15150012Fondo Nacional de Desarrollo Científico y Tecnológico 11200981Fondo Nacional de Desarrollo Científico y Tecnológico 1150766Fondo Nacional de Desarrollo Científico y Tecnológico 1231432
6 · The paper itself

Abstract

Aging is characterized by a decline in essential sensory functions, including olfaction, which is crucial for environmental interaction and survival. This decline is often paralleled by the cellular accumulation of dysfunctional mitochondria, particularly detrimental in post-mitotic cells, such as neurons. Mitochondrial stress triggers the mitochondrial unfolded protein response (UPR

Indexed as

AgingDrosophila melanogasterDrosophila ProteinsHistone-Lysine N-MethyltransferaseHistonesMitochondriaUnfolded Protein ResponseAnimalsDrosophilaMethylationReactive Oxygen SpeciesDrosophila ProteinsHistone-Lysine N-MethyltransferaseHistonesReactive Oxygen Speciesagingcell biologyD. melanogasterH3K9me3methylationmitochondrial unfolded protein responseneurodegenerationneuroscienceolfaction

Identifiers

PMID41885373
PMCPMC13155754

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.