Observational studyEuropean journal of clinical investigation2026
Liver disease in management and outcomes of European and Asian patients with atrial fibrillation: A report from two observational prospective registries.
Observational study in European journal of clinical investigation, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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1 citing paper in PubMed.
- Liver disease in management and outcomes of European and Asian patients with atrial fibrillation: A report from two observational prospective registries.European journal of clinical investigation · 2026Observational
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10 authors.
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Abstract
backgroundIn patients with atrial fibrillation (AF), the impact of liver disease (LD) on oral anticoagulant (OAC) prescription and outcomes remains unclear, as well as possible differences between European and Asian populations.
aimTo examine the impact of LD on OAC prescriptions and risks of adverse outcomes in a large cohort of European and Asian AF patients.
methodsAF patients were derived from two large observational registries held in Europe and Asia. OAC prescription and risk of outcomes were analysed according to LD at baseline. The primary outcome was the composite of all-cause death and major adverse cardiovascular events (MACEs). Logistic regression assessed associations with OAC prescription, and Cox regression analyses evaluated risks of outcomes. Interaction analyses were performed between European and Asian patients.
resultsAmong 15,681 patients (mean age 68.4 ± 10.7 years; 37.1% female), 517 (3.3%) had LD. The OAC prescription rate was similar among European and Asian individuals (6.8% vs. 82.9%, p = .113). After adjustments, LD was associated with lower OAC prescription (OR .67, 95% CI .53-.84), with a greater reduction in European than in Asian patients (p
conclusionsIn AF, LD is associated with reduced OAC prescription, especially in Europe, and a higher risk of adverse outcomes, particularly in patients not receiving OAC, with no significant differences between European and Asian cohorts.
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