ReviewJournal of immunology research2026
The Role of MicroRNAs in Treg-Derived Extracellular Vesicles: A Narrative Review Focusing on Immune-Related Diseases.
Review in Journal of immunology research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- The Role of MicroRNAs in Treg-Derived Extracellular Vesicles: A Narrative Review Focusing on Immune-Related Diseases.Journal of immunology research · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
Abstract
Regulatory T cells (Tregs) are a unique class of immunosuppressive cells that play a key role in managing immune-related diseases. Growing evidence indicates that the immunosuppressive effects of Tregs also rely on cell-to-cell interactions that are facilitated by the secretion of extracellular vesicles (EVs). Treg-derived EVs (Treg-EVs) are lipid bilayer vesicles that are released from Tregs and have been shown to promote intercellular communication and facilitate immune regulation by transferring various messenger RNAs (mRNAs), microRNAs (miRNAs), and proteins. miRNAs are small, noncoding RNA molecules that regulate gene expression after transcription and can influence multiple target genes by binding to the 3'-untranslated region (UTR) of target mRNAs to exert influence on a wide array of cellular functions. Although the roles of miRNAs and Treg-EVs in various diseases have been extensively studied, the regulatory functions of the different miRNAs within Treg-EVs in immune-related diseases remain largely unexplored. In this narrative review, we investigate the functional roles of Tregs and their derived EVs in immune regulation. Then, we discuss the specific roles of miRNAs within Treg-EVs in the context of rheumatoid arthritis (RA), inflammatory bowel disease (IBD), autoimmune vasculitis, multiple sclerosis (MS), and kidney and skin allografts by investigating recent research in autoimmune diseases and transplantation. In these situations, different Treg-EVs can support the treatment of immune-related conditions by delivering miRNAs to specific immune cells and promoting immunosuppression through multiple mechanisms.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.