Evidence map›Paper›PMID 41884973›Full record

ArticleEuropean journal of pain (London, England)2026

Bidirectional Roles of TRPV1 in a Latent Sensitization Model of Myofascial Low Back Pain.

Vivian Blechschmidt, Bastian Schlickenrieder, Jonathan R Husk, Ulrich Hoheisel, Handan Mörz, Rolf-Detlef Treede, Wolfgang Greffrath

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Article in European journal of pain (London, England), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Vivian BlechschmidtDepartment of Neurophysiology, Mannheim Center for Translational Neuroscience, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany.
Bastian SchlickenriederDepartment of Neurophysiology, Mannheim Center for Translational Neuroscience, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany.
Jonathan R HuskDepartment of Neurophysiology, Mannheim Center for Translational Neuroscience, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany.ORCID https://orcid.org/0009-0007-7669-3148
Ulrich HoheiselDepartment of Neurophysiology, Mannheim Center for Translational Neuroscience, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany.
Handan MörzDepartment of Neurophysiology, Mannheim Center for Translational Neuroscience, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany.
Rolf-Detlef TreedeDepartment of Neurophysiology, Mannheim Center for Translational Neuroscience, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany.
Wolfgang GreffrathDepartment of Neurophysiology, Mannheim Center for Translational Neuroscience, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany.ORCID https://orcid.org/0000-0001-9756-749X

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionChronic primary low back pain (cpLBP) is a global health concern with poorly understood pathomechanisms, potentially involving spinal sensitization. The capsaicin receptor TRPV1 plays a crucial role in sensitization across pain models. This study employed a rat model of cpLBP induced by two nerve growth factor (NGF) injections into lumbar muscles to explore TRPV1's roles in NGF-induced spinal sensitization. MATERIAL AND

methodsMale wildtype (WT) and TRPV1

resultsWT rats displayed latent local mechanical hypersensitivity after a single NGF injection, turning into manifest after the second, with presynaptic TRPV1 upregulation. TRPV1 DISCUSSION: TRPV1 is upregulated during manifest sensitization but is not essential for developing local or remote mechanical hypersensitivity. TRPV1 SIGNIFICANCE STATEMENT: TRPV1 contributes to NGF-induced sensitization but is not required for its development. These findings put TRPV1's potential as a therapeutic target for hyperalgesia into perspective and suggest a potential regulatory role in pain homeostasis.

Indexed as

Low Back PainMyofascial Pain SyndromesTRPV Cation ChannelsAnimalsDisease Models, AnimalFemaleHyperalgesiaMaleNerve Growth FactorPain ThresholdRatsRats, Sprague-DawleyNerve Growth FactorTrpv1 protein, ratTRPV Cation Channels

Identifiers

PMID41884973
PMCPMC13019274

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.