Evidence map›Paper›PMID 41884964›Full record

ArticleJournal of immunology research2026

Analysis of the Mediating Effect of Vitamin D via the TGF-β1/Treg Pathway in the Pathogenesis of Childhood Primary Immune Thrombocytopenia.

Peiling Li, Mengru Chen, Zhihang Wang, Rui Fan, Jia Guo, Bao Liu, Zhiyin Wang, Yanyan Ma, Dongju Zhao, Shujun Li

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of immunology research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Peiling LiDepartment of Pediatrics, The First Affiliated Hospital of Xinxiang Medical University, Weihui, Henan, China, xxmu.edu.cn.
Mengru ChenDepartment of Pediatrics, The First Affiliated Hospital of Xinxiang Medical University, Weihui, Henan, China, xxmu.edu.cn.
Zhihang WangDepartment of Pediatrics, The First Affiliated Hospital of Xinxiang Medical University, Weihui, Henan, China, xxmu.edu.cn.
Rui FanDepartment of Pediatrics, The First Affiliated Hospital of Xinxiang Medical University, Weihui, Henan, China, xxmu.edu.cn.
Jia GuoDepartment of Pediatrics, The First Affiliated Hospital of Xinxiang Medical University, Weihui, Henan, China, xxmu.edu.cn.
Bao LiuDepartment of Pediatrics, The First Affiliated Hospital of Xinxiang Medical University, Weihui, Henan, China, xxmu.edu.cn.
Zhiyin WangDepartment of Laboratory Medicine, The First Affiliated Hospital of Henan Medical University, Weihui, Henan, China.
Yanyan MaDepartment of Pediatrics, The First Affiliated Hospital of Xinxiang Medical University, Weihui, Henan, China, xxmu.edu.cn.
Dongju ZhaoDepartment of Pediatrics, The First Affiliated Hospital of Xinxiang Medical University, Weihui, Henan, China, xxmu.edu.cn.ORCID https://orcid.org/0009-0000-4964-3195
Shujun LiDepartment of Pediatrics, The First Affiliated Hospital of Xinxiang Medical University, Weihui, Henan, China, xxmu.edu.cn.ORCID https://orcid.org/0009-0001-6550-1696

Funding

Joint Construction Project of Henan Province Medical Science and Technology Research Program LHGJ20200518
6 · The paper itself

Abstract

objectiveTo investigate the role of vitamin D (VitD), transforming growth factor-β1 (TGF-β1), and regulatory T cells (Treg) in the pathogenesis of primary immune thrombocytopenia (ITP) in children.

methodsFrom February 2023 to September 2024, 51 children with ITP and 44 healthy children from the First Affiliated Hospital of Xinxiang Medical College were enrolled. The serum levels of VitD and TGF-β1 and the percentage of Treg cells in peripheral blood were measured.

resultsThere was no significant difference in age and sex between the two groups (p  > 0.05). ITP group VitD, TGF-β1, and the level of Treg cells were significantly lower than those of the control group (p  < 0.05). In the ITP group, VitD and TGF-β1 (r = 0.421), Treg cells (r = 0.516), TGF-β1 and Treg cells (r = 0.563), and platelet count (r = 0.399, 0.305, 0.361, respectively, p  < 0.05). The median model analysis showed that VitD had a significant negative overall effect on ITP risk (regression coefficient = -0.014, p = 0.004), but its direct effect was no longer significant after the introduction of TGF-β1 and Treg, suggesting a complete mediation effect, where the path of VitD affecting ITP via TGF-β1 is significant (effect value = -0.015, p  < 0.001), but the mediated pathway involving Treg was not statistically significant.

conclusionThere is dysregulation of VitD, TGF-β1, and Treg cells in newly diagnosed children with ITP. TGF-β1 may be a key mediator of the regulation of ITP by VitD, suggesting the potential value of TGF- β1 as an intervening target.

Indexed as

Purpura, Thrombocytopenic, IdiopathicT-Lymphocytes, RegulatoryTransforming Growth Factor beta1Vitamin DChildChild, PreschoolFemaleHumansInfantMaleSignal TransductionTGFB1 protein, humanTransforming Growth Factor beta1Vitamin Dimmune thrombocytopeniaregulatory T cellstransforming growth factor-beta 1vitamin D

Identifiers

PMID41884964
PMCPMC13140290

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.