ArticleFrontiers in immunology2026
Clinical characteristics and decreased CD4
Article in Frontiers in immunology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: Immune thrombocytopenia (ITP) exhibits distinct epidemiological characteristics in terms of age and sex distribution. In contrast to adult ITP, the clinical features and immunological mechanisms underlying pediatric ITP remain incompletely understood. Objective: To analyze the clinical characteristics, treatment response and immunological profiles of newly diagnosed pediatric ITP patients, in order to provide a reference for clinical diagnosis and treatment. Methods: This study enrolled 240 newly diagnosed pediatric ITP patients. Demographic characteristics, predisposing factors, clinical manifestations, treatment response, and prognosis were analyzed. Lymphocyte subsets were assessed by flow cytometry, and serum cytokine levels were measured using ELISA. Results: The <1 year age group constituted the largest subgroup (51.67%). Gender distribution differed significantly across the age groups ( Conclusion: Pediatric ITP demonstrates significant differences from adult ITP in age distribution, sex characteristics, and prognosis. The underlying immune dysregulation involves decreased regulatory T cells, significantly reduced levels of their specific anti-inflammatory cytokine IL-35 and concomitant expansion of CD8
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