Evidence map›Paper›PMID 41884840›Full record

ArticleFrontiers in immunology2026

Distinct macular structural and microvascular alterations differentiate neuromyelitis optica spectrum disorder from myelin oligodendrocyte glycoprotein antibody-associated disease in optic neuritis.

Mi Zhang, Zhongzhong Liu, Yunfei Li, Yanli Li, Ruili Ma, Qingli Lu, Pei Liu, Yan Liu, Qiaoqiao Chang, Yan Wang and 14 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in immunology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

24 authors.

Mi Zhang *Department of Neuro-ophthalmology, Xi'an No.1 Hospital, The First Affiliated Hospital of Northwest University, Xi'an, Shaanxi, China.
Zhongzhong Liu *Department of Neuro-ophthalmology, Xi'an No.1 Hospital, The First Affiliated Hospital of Northwest University, Xi'an, Shaanxi, China.
Yunfei Li *Department of Sensory Control, Xi'an No.1 Hospital, The First Affiliated Hospital of Northwest University, Xi'an, Shaanxi, China.
Yanli LiKey Laboratory of Resource Biology and Biotechnology in Western China, Ministry of Education, School of Medicine, Northwest University, Xi'an, Shaanxi, China.
Ruili MaKey Laboratory of Resource Biology and Biotechnology in Western China, Ministry of Education, School of Medicine, Northwest University, Xi'an, Shaanxi, China.
Qingli LuDepartment of Neuro-ophthalmology, Xi'an No.1 Hospital, The First Affiliated Hospital of Northwest University, Xi'an, Shaanxi, China.
Pei LiuDepartment of Neuro-ophthalmology, Xi'an No.1 Hospital, The First Affiliated Hospital of Northwest University, Xi'an, Shaanxi, China.
Yan LiuDepartment of Neuro-ophthalmology, Xi'an No.1 Hospital, The First Affiliated Hospital of Northwest University, Xi'an, Shaanxi, China.
Qiaoqiao ChangDepartment of Neuro-ophthalmology, Xi'an No.1 Hospital, The First Affiliated Hospital of Northwest University, Xi'an, Shaanxi, China.
Yan WangDepartment of Neuro-ophthalmology, Xi'an No.1 Hospital, The First Affiliated Hospital of Northwest University, Xi'an, Shaanxi, China.
Chensheng SongDepartment of Neuro-ophthalmology, Xi'an No.1 Hospital, The First Affiliated Hospital of Northwest University, Xi'an, Shaanxi, China.
Yan HuoDepartment of Neuro-ophthalmology, Xi'an No.1 Hospital, The First Affiliated Hospital of Northwest University, Xi'an, Shaanxi, China.
Lanping RaoDepartment of Neuro-ophthalmology, Xi'an No.1 Hospital, The First Affiliated Hospital of Northwest University, Xi'an, Shaanxi, China.
Shundao CaoDepartment of Neuro-ophthalmology, Xi'an No.1 Hospital, The First Affiliated Hospital of Northwest University, Xi'an, Shaanxi, China.
Ning WangDepartment of Neuro-ophthalmology, Xi'an No.1 Hospital, The First Affiliated Hospital of Northwest University, Xi'an, Shaanxi, China.
Guo LiDepartment of Neuro-ophthalmology, Xi'an No.1 Hospital, The First Affiliated Hospital of Northwest University, Xi'an, Shaanxi, China.
Fanyan WuDepartment of Neuro-ophthalmology, Xi'an No.1 Hospital, The First Affiliated Hospital of Northwest University, Xi'an, Shaanxi, China.
Tong LiuDepartment of Neuro-ophthalmology, Xi'an No.1 Hospital, The First Affiliated Hospital of Northwest University, Xi'an, Shaanxi, China.
Linna PengDepartment of Neuro-ophthalmology, Xi'an No.1 Hospital, The First Affiliated Hospital of Northwest University, Xi'an, Shaanxi, China.
Yunlong HaoSchool of Medicine, Xizang Minzu University, Xianyang, Shaanxi, China.
Zijing CaoSchool of Medicine, Xizang Minzu University, Xianyang, Shaanxi, China.
Xuemei LinDepartment of Neuro-ophthalmology, Xi'an No.1 Hospital, The First Affiliated Hospital of Northwest University, Xi'an, Shaanxi, China.
Xiaolai ZhouState Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-Sen University, Guangzhou, Guangdong, China.
Songdi WuDepartment of Neuro-ophthalmology, Xi'an No.1 Hospital, The First Affiliated Hospital of Northwest University, Xi'an, Shaanxi, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: Neuromyelitis optica spectrum disorder (NMOSD) and myelin oligodendrocyte glycoprotein antibody-associated disease (MOGAD) are among the leading causes of optic neuritis. This study aimed to examine differences in macular retinal structure and microvascular characteristics between affected and unaffected eyes in individuals with NMOSD and MOGAD. Method: This cross-sectional study enrolled both eyes of patients diagnosed with optic neuritis (ON)secondary to NMOSD (22 patients: 36 NMOSD-ON eyes and 8 NMOSD-NON eyes), MOGAD (23 patients: 34 MOG-ON eyes and 12 MOG-NON eyes), and 20 age- and sex-matched healthy controls (HCs, 40 eyes) recruited from the First Affiliated Hospital of Northwest University (Xi'an No.1 Hospital) between February 2023 and January 2025. Microvascular density (MVD), vascular density (VD), blood flow area (BFA), and macular ganglion cell-inner plexiform layer (GCIPL) thickness were measured and analyzed. Result: Both NMOSD-ON and MOG-ON eyes showed significant reductions in MVD of radial peripapillary capillary plexus (RPCP); MVD, VD, and BFA of superficial vascular complex (SVC); BFA of deep vascular complex (DVC); and GCIPL thickness compared with HCs ( Conclusion: Both NMOSD and MOGAD cause macular structural and microvascular damage associated with reduced BCVA. Decreased CC BFA may aid in distinguishing NMOSD from MOGAD.

Indexed as

Macula LuteaMicrovesselsMyelin-Oligodendrocyte GlycoproteinMyelin Oligodendrocyte Glycoprotein Antibody-Associated DiseaseNeuromyelitis OpticaOptic NeuritisRetinal VesselsAdultCross-Sectional StudiesDiagnosis, DifferentialFemaleHumansMaleMiddle AgedTomography, Optical CoherenceYoung AdultMyelin-Oligodendrocyte Glycoproteinmacular microvasculaturemyelin oligodendrocyte glycoprotein antibody-associated diseaseneuromyelitis optica spectrum disorderoptical coherence tomography angiographyoptic neuritisretinal biomarkers

Identifiers

PMID41884840
PMCPMC13010087

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.