ArticleSurgery open science2026
Short-term surgical outcomes for patients with non-functional pancreatic neuroendocrine tumors are unaffected by chronological age.
Article in Surgery open science, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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12 authors.
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Abstract
Background: Non-functional pancreatic neuroendocrine tumors (NF-pNETs) are increasingly diagnosed, particularly in older adults, largely due to widespread cross-sectional imaging. Patients with NF-pNETs typically have a soft pancreas and a small main pancreatic duct, which puts them at high risk for postoperative pancreatic fistula B/C, significantly impacting postoperative morbidity and mortality. Given the rising incidence of NF-pNETs and ongoing uncertainty about optimal treatment in older individuals, this study evaluates postoperative outcomes and histopathological differences between older and younger patient cohorts. Material and methods: In this study, a total of 171 patients that underwent any type of pancreatic resection for NF-pNETs between 2003 and 2023 at our institution, were investigated retrospectively upon demographic data, postoperative complications, duration of hospital stay and tumor histology. Patients were stratified into younger (< 70 years) and older (> 70 years) groups. Postoperative short-term outcomes were compared between both groups. Results: A total of 171 patients underwent pancreatic resection for NF-pNETs, including 129 younger (<70 years) and 42 older (≥70 years) patients. Older patients exhibited a markedly higher prevalence of cardiac (62% vs. 30%) and pulmonary conditions (15% vs. 5%) compared to their younger counterparts. Surgical approaches and tumor locations were similar. Postoperative outcomes, including POPF, PPH, DGE, LOS, and 30-day mortality, did not significantly differ between groups. Ideal outcome (IO) was achieved in 45.5% of younger and 37.2% of older patients (p = NS). Oncological features such as tumor stage, lymph node involvement, grading, and Ki-67 index were comparable. Conclusion: Surgical resection for NF-pNETs appears to be a safe option in older patients (≥70 years), as chronological age by itself does not significantly impact postoperative outcomes.
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