ArticleIndian journal of dermatology
Prevalence of Metabolic Syndrome in Chronic Spontaneous Urticaria and Associated Risk-Factors-An Analytical Cross-Sectional Study.
Article in Indian journal of dermatology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: Chronic spontaneous urticaria (CSU) is a persistent low-grade inflammatory condition, which may be associated with metabolic syndrome (MetS). Objective: To estimate the prevalence of MetS in CSU patients and identify associated risk factors. Methods: We conducted a cross-sectional study including 74 CSU patients and 58 age-and-sex-matched healthy controls. Disease duration was assessed in all CSU patients along with disease activity and control using the UAS7 and UCT scores respectively. MetS was diagnosed by NCEP-ATP III criteria in all study participants. Additional biochemical parameters included absolute eosinophil and basophil counts. The neutrophil-lymphocyte ratio (NLR), platelet-lymphocyte ratio (PLR), mean platelet volume (MPV), and serum total IgE, to identify potential risk factors for MetS. Results: CSU patients (mean age 35.4 ± 11.5 years, M: F 36:38) showed a higher prevalence of MetS, vs. healthy controls (mean age 31.9 ± 9.7 years, M: F 20:38), although statistically comparable [cases vs. controls 24.3% vs. 20.7%, Conclusion: MetS is more prevalent in CSU patients compared to healthy controls, although statistically comparable. All CSU patients need screening for underlying MetS, independent of their disease characteristics. Notably, higher age at presentation, higher total serum IgE, higher MPV, and raised FBS may aggravate the risk for MetS.
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