Evidence map›Paper›PMID 41884709›Full record

ArticleFrontiers in bioinformatics2026

Visualizing the multidimensional landscape of biological variation in modern microscopy.

Gesine F Müller, Torben Göpel, Nico Scherf, Jan Huisken

Abstract read
In one paragraph

Article in Frontiers in bioinformatics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Gesine F MüllerMultiscale Biology, Faculty of Biology and Psychology, Georg-August-University Göttingen, Göttingen, Germany.
Torben GöpelMultiscale Biology, Faculty of Biology and Psychology, Georg-August-University Göttingen, Göttingen, Germany.
Nico ScherfMethods and Development Group Neural Data Science and Statistical Computing, Max Planck Institute for Human Cognitive and Brain Sciences, Leipzig, Germany.
Jan HuiskenMultiscale Biology, Faculty of Biology and Psychology, Georg-August-University Göttingen, Göttingen, Germany.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Variation is a foundational biological principle that has historically been marginalized-both due to limited experimental accessibility and because of idealized, stereotypic blueprints rooted in essentialist thinking. With the advent of genetics and quantitative biology investigating environmental influences on the phenotype, variation was redefined from mere noise to a fundamental property. Modern light sheet microscopy now enables high-resolution, long-term imaging of dynamic processes across large populations, making it possible to systematically study phenotypic variation

Indexed as

biological variationlight sheet microscopyrepresentative samplingsmart microscopyvisualization

Identifiers

PMID41884709
PMCPMC13010058

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.