ArticleIBRO neuroscience reports2026
The impact of radiation-induced temporal lobe injury on cognition and structure across the whole brain in nasopharyngeal carcinoma patients.
Article in IBRO neuroscience reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed, 1 synthesis or guideline pooled it.
- Longitudinal Neurocognitive Changes for Patients With Hematologic Malignancies Undergoing Hematopoietic Stem Cell Transplantation: A Systematic Review With Structured Narrative Synthesis.European journal of haematology · 2026Pooled it
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Introduction: Radiation-induced temporal lobe injury (RI-TLI) is one of the most common late-stage complications after radiotherapy for nasopharyngeal carcinoma (NPC), which seriously affects patients' cognitive function and quality of life. However, the mechanism by which RI-TLI affects the gray matter (GM) and white matter (WM) across the whole brain, leading to cognitive impairment, is currently unclear in NPC patients. Methods: One year after the end of radiotherapy, 32 NPC patients with RI-TLI (RI-TLI group) and 38 NPC patients without RI-TLI (nRI-TLI group) were included in this study. The Montreal Cognitive Assessment (MoCA) was applied to evaluate the differences of cognitive function between RI-TLI and nRI-TLI groups. In addition, T1 structural magnetic resonance imaging data were acquired, and then the whole-brain voxel-based morphometry was employed to compare the differences of GM and WM between groups. The relationships between GM and WM of abnormal brain regions and MoCA scores were explored. Finally, receiver operating characteristic (ROC) curve was performed to determine the suitability of altered brain structure for distinguishing RI-TLI from nRI-TLI. Results: Compared with nRI-TLI group, RI-TLI group exhibited decreased attention, delayed recall scores and total scores of MoCA. In addition, RI-TLI group exhibited decreased GM volume in the right middle temporal gyrus, left hippocampus, right superior temporal gyrus, right superior frontal gyrus and decreased GM density in the left superior frontal gyrus, right superior frontal gyrus, right supplementary motor area. Moreover, RI-TLI group demonstrated decreased WM volume in the right inferior temporal gyrus, left hippocampus, right superior temporal gyrus, right medial superior frontal gyrus and decreased WM density in the left superior frontal gyrus, right superior frontal gyrus. The attention scores of MoCA were positively associated with GM volume of the right superior temporal gyrus, right superior frontal gyrus, GM density of the left superior frontal gyrus, right superior frontal gyrus, WM density of the left superior frontal gyrus. The delayed recall scores of MoCA were positively related to GM volume of the left hippocampus, WM density of the left superior frontal gyrus. The total scores of MoCA were positively associated with GM volume of the left hippocampus, WM volume of the left hippocampus, right superior temporal gyrus, WM density of the left superior frontal gyrus. ROC analysis demonstrated that altered GM and WM might be helpful for distinguishing RI-TLI from nRI-TLI. Conclusion: Compared to nRI-TLI patients, RI-TLI patients exhibit more severe cognitive impairment alongside decreased GM and WM in both the temporal lobe and prefrontal regions. The observed structural alterations are associated with the severity of cognitive deficits and may serve as potential neuroimaging markers for RI-TLI.
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