Evidence map›Paper›PMID 41884535›Full record

ArticleFrontiers in cellular and infection microbiology2026

Pathology and pathogenesis of bluetongue virus serotype 24 during experimental infection in native sheep.

S Vineetha, M Saminathan, Madhulina Maity, Gaurav K Sharma, Mahajan Sonalika, Y Krishnajyothi, Sanchay K Biswas, A Arun Prince Milton, M S L Carvajal, Sushila Maan and 2 more

Abstract read
In one paragraph

Article in Frontiers in cellular and infection microbiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

S VineethaCentre for Animal Disease Research and Diagnosis (CADRAD), Indian Council of Agricultural Research (ICAR)-Indian Veterinary Research Institute, Bareilly, Uttar Pradesh, India.
M SaminathanDivision of Virology, ICAR-Indian Veterinary Research Institute, Mukteshwar, Uttarakhand, India.
Madhulina MaityCentre for Animal Disease Research and Diagnosis (CADRAD), Indian Council of Agricultural Research (ICAR)-Indian Veterinary Research Institute, Bareilly, Uttar Pradesh, India.
Gaurav K SharmaCentre for Animal Disease Research and Diagnosis (CADRAD), Indian Council of Agricultural Research (ICAR)-Indian Veterinary Research Institute, Bareilly, Uttar Pradesh, India.
Mahajan SonalikaDivision of Biological Standardization, Indian Council of Agricultural Research (ICAR)-Indian Veterinary Research Institute, Bareilly, Uttar Pradesh, India.
Y KrishnajyothiDepartment of Animal Husbandry, Veterinary Biological and Research Institute, Hyderabad, Telangana, India.
Sanchay K BiswasCentre for Animal Disease Research and Diagnosis (CADRAD), Indian Council of Agricultural Research (ICAR)-Indian Veterinary Research Institute, Bareilly, Uttar Pradesh, India.
A Arun Prince MiltonDivision of Animal and Fisheries Sciences, ICAR-Research Complex for North Eastern Hill Region, Umiam, Meghalaya, India.
M S L CarvajalDepartment of Pathobiological Sciences, School of Veterinary Medicine, University of Wisconsin - Madison, Madison, WI, United States.
Sushila MaanDepartment of Biotechnology, College of Veterinary Sciences, Lala Lajpat Rai University of Veterinary and Animal Sciences (LUVAS), Hisar, India.
Yashpal Singh MalikDivision of Virology, ICAR-Indian Veterinary Research Institute, Mukteshwar, Uttarakhand, India.
K P SinghCentre for Animal Disease Research and Diagnosis (CADRAD), Indian Council of Agricultural Research (ICAR)-Indian Veterinary Research Institute, Bareilly, Uttar Pradesh, India.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: Bluetongue virus (BTV) is a species of genus Methods: Six native sheep were infected intradermally with BTV-24 at 10 Results: The BTV-24-infected animals showed pyrexia, conjunctival and oral mucosal congestion, cyanosis of tongue, serous to catarrhal nasal discharge, and viremia. Gross pathological lesions were observed in the lymph nodes, lungs, and kidneys, with the lymph nodes being enlarged, edematous, and hemorrhagic. Subintimal hemorrhage at the base of the pulmonary artery (pathognomonic lesion of BT) was observed at 7 DPI. Histopathological lesions were prominent in lymph nodes, spleen, heart, lungs, and cerebral endothelium. Severe hemosiderosis in spleen, and hemorrhages and hyalinization of tunica media in pulmonary artery at 7 DPI were observed. Development of clinical signs and gross and histopathological lesions in BTV-24-infected animals emphasized the moderate progression of disease and enhanced virulence of the serotype. Humoral immune response was significantly high at 5, 11, 16, 21, 45, and 60 DPI. Cell-mediated immune response-like kinetics of CD4 Conclusion: The results of this study can be used to formulate effective preventive and control measures and to develop a suitable vaccine against BTV-24 to minimize economic losses.

Indexed as

BluetongueBluetongue virusAnimalsAntibodies, ViralDisease Models, AnimalImmunohistochemistryIndiaLymph NodesSerogroupSheepSpleenViral LoadAntibodies, Viralbluetongue virus serotype 24experimental infectionimmune responsepathogenesispathologysheep

Identifiers

PMID41884535
PMCPMC13008964

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.