ArticleFrontiers in cellular and infection microbiology2026
Perillaldehyde combined with domiphen: synergistic bactericidal and anti-biofilm activity against
Article in Frontiers in cellular and infection microbiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Introduction: Biofilms formed by pathogenic bacteria such as Methods: The antimicrobial activity of perillaldehyde and domiphen, alone and in combination, was assessed against Results: The combination of perillaldehyde and domiphen showed synergistic effects against both pathogenic strains, with a fractional inhibitory concentration index of less than 0.36. The combination of 1 μL/mL perillaldehyde and 1 μg/mL domiphen dispersed more than 53% of the biofilm mass in both Discussion: These results indicate that the novel combination of perillaldehyde and domiphen has the potential to decrease biofilm formation on various industrial material surfaces.
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