Trial reportDrug design, development and therapy2026
Comparison of the Effects of Glycopyrrolate and Atropine on Postoperative Delirium in Older Adult Patients Undergoing Laparoscopic Colorectal Surgery: A Randomized Controlled Trial.
Trial report in Drug design, development and therapy, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Authors and funding
9 authors.
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No grant is acknowledged in the PubMed record.
Abstract
Background: Postoperative delirium (POD) is a common complication that hinders recovery in older patients. This study aimed to compare the effects of glycopyrrolate and atropine, used to counteract the peripheral effects of neostigmine, on POD incidence in older patients undergoing laparoscopic colorectal surgery. Methods: This single-centre, double-blind, randomized controlled trial recruited patients (aged 65-80 years) undergoing laparoscopic colorectal surgery. Patients were randomized to receive either glycopyrrolate (0.04 mg kg Results: Among 121 patients, the glycopyrrolate group had a significantly lower incidence of POD compared with the atropine group (11.7% vs 27.9%; relative risk, 0.42; 95% confidence interval, 0.19-0.94; p = 0.045). Glycopyrrolate better maintained baseline heart rate and mean arterial pressure. No significant differences were observed in plasma levels of neurofilament light chain, neuron-specific enolase, and Tau protein between groups at different time points. Conclusion: The combination of glycopyrrolate and neostigmine was associated with a lower incidence of POD than atropine in older adults undergoing laparoscopic colorectal surgery. Registration: Chinese Clinical Trial Registry, ChiCTR2300072798.
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