Evidence map›Paper›PMID 41884466›Full record

ReviewAnnals of intensive care2026

Personalized positive-end expiratory pressure using electrical impedance tomography in ARDS patients: a systematic review and meta-analysis.

Michela Rauseo, Danila Azzolina, Gaetano Scaramuzzo, Mohd Rashid Khan, Paolo Vetuschi, Francesco Paolo Padovano, Antonello Discenza, Lucia Distaso, Lucia Mirabella, Antonella Cotoia and 2 more

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Annals of intensive care, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Michela RauseoUniversity of Foggia, Department of Medical and Surgical Science, Anesthesia and Intensive Care Medicine, Policlinico Riuniti di Foggia, Italy.
Danila AzzolinaBiostatistics and Clinical Trial Methodology Unit, Clinical Research Center DEMeTra, Department of Translational Medical Science, University of Naples Federico II, Naples, Italy.
Gaetano ScaramuzzoDepartment of Translational Medicine, University of Ferrara, Saint' Anna Hospital, Ferrara, Italy.
Mohd Rashid KhanDepartment of Cardiac, Thoracic, Vascular Sciences and Public Health, University of Padua, Padua, Italy.
Paolo VetuschiDepartment of Cardiac Anesthesia, Policlinico Riuniti di Foggia, Italy.
Francesco Paolo PadovanoDepartment of Cardiac Anesthesia, Policlinico Riuniti di Foggia, Italy.
Antonello DiscenzaUniversity of Foggia, Department of Medical and Surgical Science, Anesthesia and Intensive Care Medicine, Policlinico Riuniti di Foggia, Italy.
Lucia DistasoUniversity of Foggia, Department of Medical and Surgical Science, Anesthesia and Intensive Care Medicine, Policlinico Riuniti di Foggia, Italy.
Lucia MirabellaUniversity of Foggia, Department of Medical and Surgical Science, Anesthesia and Intensive Care Medicine, Policlinico Riuniti di Foggia, Italy.
Antonella CotoiaUniversity of Foggia, Department of Medical and Surgical Science, Anesthesia and Intensive Care Medicine, Policlinico Riuniti di Foggia, Italy.
Savino SpadaroDepartment of Translational Medicine, University of Ferrara, Saint' Anna Hospital, Ferrara, Italy.
Gilda CinnellaUniversity of Foggia, Department of Medical and Surgical Science, Anesthesia and Intensive Care Medicine, Policlinico Riuniti di Foggia, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Objective: Personalized mechanical ventilation strategies can improve outcomes in patients with Acute Respiratory Distress Syndrome (ARDS). However, the optimal method for titrating positive end-expiratory pressure (PEEP) remains controversial. Electrical Impedance Tomography (EIT), by enabling real-time, regional assessment of lung regional characteristics, offers potential advantages to guiding PEEP titration as compared to conventional methods. Data sources and study selection: We conducted a systematic review and meta-analysis of randomized clinical trials and observational studies comparing EIT-guided versus conventional PEEP titration in adult ARDS. The review was conducted according to the PRISMA 2020 guidelines. Moreover, the review was conducted in accordance with the MOOSE (Meta-analysis of Observational Studies in Epidemiology) recommendations, where applicable, and with the registered protocol (PROSPERO ID: CRD420251015187). The primary outcomes were the PaO Data extraction and data synthesis: Nine studies (n = 356 patients) were included. EIT-guided PEEP titration was associated with an improvement in oxygenation, expressed as PaO Conclusion: EIT-guided PEEP titration improves oxygenation and respiratory system compliance in patients with ARDS, supporting its role as a physiology-based strategy for ventilatory personalization. Further evidence are needed to determine whether these physiological improvements translate into better clinical outcomes.

Indexed as

ARDSDriving pressureElectrical impedance tomographyLung mechanicsMechanical power.Mechanical ventilationOxygenationPEEP titrationRespiratory compliance

Identifiers

PMID41884466
PMCPMC13010124

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.