Enantioselective Synthesis of Axially Chiral Spiro[3.3]heptanes by Site-Selective C-H Functionalization.

Duc Ly, Ziyi Chen, Djamaladdin G Musaev, Huw M L Davies

Abstract read

In one paragraph

Article in ACS catalysis, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Duc LyDepartment of Chemistry, Emory University, 1515 Dickey Drive, Atlanta, Georgia 30322, United States.ORCID https://orcid.org/0000-0002-0829-5080

Ziyi ChenDepartment of Chemistry, Emory University, 1515 Dickey Drive, Atlanta, Georgia 30322, United States.ORCID https://orcid.org/0000-0002-8093-8466

Djamaladdin G MusaevDepartment of Chemistry, Emory University, 1515 Dickey Drive, Atlanta, Georgia 30322, United States.ORCID https://orcid.org/0000-0003-1160-6131

Huw M L DaviesDepartment of Chemistry, Emory University, 1515 Dickey Drive, Atlanta, Georgia 30322, United States.ORCID https://orcid.org/0000-0001-6254-9398

Funding

Novel Bowl-shaped Catalysts for Selective C-H FunctionalizationR35GM158221 · NIGMS · EMORY UNIVERSITY · PI HUW M DAVIES · 2025 to 2026

$744k

NIGMS NIH HHS R35 GM158221

6 · The paper itself

Abstract

The enantioselective synthesis of axially chiral 2,6-disubstituted spiro[3.3]-heptanes is challenging because the differentiating functionalities are far apart from each other. The known enantioselective methods to generate these compounds have relied on the use of enzymatic processes. The current study achieves a highly regio-, diastereo-, and enantioselective entry to the 2,6-disubstituted spiro[3.3]-heptanes by desymmetrizing 2-substituted spiro[3.3]-heptanes using rhodium-catalyzed C-H functionalization by donor/acceptor carbenes derived from aryldiazoacetates and styryldiazoacetates. The optimum catalyst is dirhodium tetrakis-(4,4'-(3,5-ditertbutylphenyl)-6,6'-dichlorobinaphthylphosphate) (Rh

Indexed as

asymmetric catalysisaxially chiralC−H functionalizationchiral spiranesdesymmetrizationrhodium carbenespiro[3.3]heptane

Identifiers

PMID41884409

DOI10.1021/acscatal.6c00560

PMCPMC13010244

What OpenQuestion holds

Textmetadata

LicenceCC BY

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.