ArticleDose-response : a publication of International Hormesis Society
Article in Dose-response : a publication of International Hormesis Society. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Ionizing radiation (IR) has the potential to harm cellular macromolecules, raising concerns across a range of exposure contexts. This study investigates the radioprotective potential of Research Design: The GRE composition was analysed using ultra-performance liquid chromatography (UPLC). Peripheral blood mononuclear cells were treated with 0.25-2 mg/mL GRE 24 hours prior to 0.5 and 2 Gy gamma radiation exposure (Co-60 source). Oxidative stress and antioxidant responses were evaluated via lipid peroxidation products, reduced glutathione, and pro-oxidant/antioxidant balance assays. Genomic damage was assessed using the micronuclei test, comet and colorimetric DNA fragmentation assay, and DNA repair was assessed through evaluation of gene expression levels that are involved in base excision repair. Results: The presence of gentiopicroside, loganic acid, sweroside, swertiamarin, and rosmarinic acid was confirmed by UPLC analysis. GRE pretreatment significantly improved cell viability, reduced oxidative and genomic damage, and enhanced antioxidative responses in irradiated cells. Conclusions: Natural compounds in GRE induce cellular responses that attenuate sublethal radiation damage in human PBMCs
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Registered trials
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